BDBM50436053 CHEMBL2396992
SMILES: Cc1[nH]c2cc(Cl)cc(Cl)c2c1CCN
InChI Key: InChIKey=JCTJISIFGZHOFY-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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GTPase KRas (Homo sapiens (Human)) | BDBM50436053 (CHEMBL2396992) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 1.55E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of KRas (unknown origin) by nucleotide release assay | Bioorg Med Chem Lett 25: 2461-8 (2015) Article DOI: 10.1016/j.bmcl.2015.04.089 BindingDB Entry DOI: 10.7270/Q2SF2XVC | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
GTPase KRas (Homo sapiens (Human)) | BDBM50436053 (CHEMBL2396992) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 3.42E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona Curated by ChEMBL | Assay Description Inhibition of full-length human KRas4B (amino acids 1 to 188)-SOS interaction assessed as inhibition of nucleotide exchange activity | J Med Chem 56: 5219-30 (2014) Article DOI: 10.1021/jm3017706 BindingDB Entry DOI: 10.7270/Q2GB25F2 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
GTPase KRas (Homo sapiens (Human)) | BDBM50436053 (CHEMBL2396992) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 1.55E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Arizona Curated by ChEMBL | Assay Description Inhibition of full-length human KRas4B (amino acids 1 to 188)-SOS interaction assessed as inhibition of SOS-mediated nucleotide release activity | J Med Chem 56: 5219-30 (2014) Article DOI: 10.1021/jm3017706 BindingDB Entry DOI: 10.7270/Q2GB25F2 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |