BDBM50437023 CHEMBL2403059
SMILES: COc1cc(cc(c1)-c1nc(Nc2ccc(N3CCN(C)CC3)c(OC)c2)ncc1Cl)C#N
InChI Key: InChIKey=LYPJJBGYRGFAOQ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PAK 1/CDC42 (Homo sapiens (Human)) | BDBM50437023 (CHEMBL2403059) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.24E+4 | n/a | n/a | n/a | n/a |
Astex Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of PAK1 in human OVCAR3 cells assessed as MEK phosphorylation by TR-FRET assay | Bioorg Med Chem Lett 23: 4072-5 (2013) Article DOI: 10.1016/j.bmcl.2013.05.059 BindingDB Entry DOI: 10.7270/Q25M674B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PAK 1/CDC42 (Homo sapiens (Human)) | BDBM50437023 (CHEMBL2403059) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 487 | n/a | n/a | n/a | n/a | n/a | n/a |
Astex Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant PAK1 using MBP as substrate by scintillation counting analysis in presence of [gamma-32P]ATP | Bioorg Med Chem Lett 23: 4072-5 (2013) Article DOI: 10.1016/j.bmcl.2013.05.059 BindingDB Entry DOI: 10.7270/Q25M674B | |||||||||||
More data for this Ligand-Target Pair |