Found 4 hits for monomerid = 50437059 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50437059
(CHEMBL2403366)Show SMILES COc1ccc2NC(=O)\C(=C/c3cc4CN(CCc4[nH]3)C(=O)CCN)c2c1 Show InChI InChI=1S/C20H22N4O3/c1-27-14-2-3-18-15(10-14)16(20(26)23-18)9-13-8-12-11-24(19(25)4-6-21)7-5-17(12)22-13/h2-3,8-10,22H,4-7,11,21H2,1H3,(H,23,26)/b16-9- | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of PDGFRa (unknown origin) |
Bioorg Med Chem Lett 23: 4085-90 (2013)
Article DOI: 10.1016/j.bmcl.2013.05.054 BindingDB Entry DOI: 10.7270/Q2SB474D |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase receptor Ret
(Homo sapiens (Human)) | BDBM50437059
(CHEMBL2403366)Show SMILES COc1ccc2NC(=O)\C(=C/c3cc4CN(CCc4[nH]3)C(=O)CCN)c2c1 Show InChI InChI=1S/C20H22N4O3/c1-27-14-2-3-18-15(10-14)16(20(26)23-18)9-13-8-12-11-24(19(25)4-6-21)7-5-17(12)22-13/h2-3,8-10,22H,4-7,11,21H2,1H3,(H,23,26)/b16-9- | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of RET (unknown origin) |
Bioorg Med Chem Lett 23: 4085-90 (2013)
Article DOI: 10.1016/j.bmcl.2013.05.054 BindingDB Entry DOI: 10.7270/Q2SB474D |
More data for this Ligand-Target Pair | |
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)
(Homo sapiens (Human)) | BDBM50437059
(CHEMBL2403366)Show SMILES COc1ccc2NC(=O)\C(=C/c3cc4CN(CCc4[nH]3)C(=O)CCN)c2c1 Show InChI InChI=1S/C20H22N4O3/c1-27-14-2-3-18-15(10-14)16(20(26)23-18)9-13-8-12-11-24(19(25)4-6-21)7-5-17(12)22-13/h2-3,8-10,22H,4-7,11,21H2,1H3,(H,23,26)/b16-9- | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of human LRRK2 (1885 to 2132) using 5-Fluo-Ahx-RLGRDKYKTLRQIRQGNTK-OH as substrate after 60 mins by fluorescence assay |
Bioorg Med Chem Lett 23: 4085-90 (2013)
Article DOI: 10.1016/j.bmcl.2013.05.054 BindingDB Entry DOI: 10.7270/Q2SB474D |
More data for this Ligand-Target Pair | |
ALK tyrosine kinase receptor
(Homo sapiens (Human)) | BDBM50437059
(CHEMBL2403366)Show SMILES COc1ccc2NC(=O)\C(=C/c3cc4CN(CCc4[nH]3)C(=O)CCN)c2c1 Show InChI InChI=1S/C20H22N4O3/c1-27-14-2-3-18-15(10-14)16(20(26)23-18)9-13-8-12-11-24(19(25)4-6-21)7-5-17(12)22-13/h2-3,8-10,22H,4-7,11,21H2,1H3,(H,23,26)/b16-9- | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of ALK (unknown origin) |
Bioorg Med Chem Lett 23: 4085-90 (2013)
Article DOI: 10.1016/j.bmcl.2013.05.054 BindingDB Entry DOI: 10.7270/Q2SB474D |
More data for this Ligand-Target Pair | |