Found 8 hits for monomerid = 50437505 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Focal adhesion kinase 1
(Homo sapiens (Human)) | BDBM50437505
(CHEMBL2409778)Show SMILES Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)ccc2F)n(C)n1 Show InChI InChI=1S/C22H20FN7O3/c1-12-9-18(29(2)27-12)21(32)24-17-10-14(5-7-16(17)23)33-15-6-8-19-25-22(28-30(19)11-15)26-20(31)13-3-4-13/h5-11,13H,3-4H2,1-2H3,(H,24,32)(H,26,28,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description Inhibition of N-terminal FLAG-tagged recombinant FAK (unknown origin) expressed in baculovirus expression system using biotinylated poly-GluTyr as su... |
Bioorg Med Chem 21: 4714-29 (2013)
Article DOI: 10.1016/j.bmc.2013.04.042 BindingDB Entry DOI: 10.7270/Q2ZS2XZQ |
More data for this Ligand-Target Pair | |
Insulin-like growth factor I receptor
(Homo sapiens (Human)) | BDBM50437505
(CHEMBL2409778)Show SMILES Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)ccc2F)n(C)n1 Show InChI InChI=1S/C22H20FN7O3/c1-12-9-18(29(2)27-12)21(32)24-17-10-14(5-7-16(17)23)33-15-6-8-19-25-22(28-30(19)11-15)26-20(31)13-3-4-13/h5-11,13H,3-4H2,1-2H3,(H,24,32)(H,26,28,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description Inhibition of IGF1-R (unknown origin) using biotinylated poly-GluTyr as substrate by AlphaScreen assay |
Bioorg Med Chem 21: 4714-29 (2013)
Article DOI: 10.1016/j.bmc.2013.04.042 BindingDB Entry DOI: 10.7270/Q2ZS2XZQ |
More data for this Ligand-Target Pair | |
Insulin receptor
(Homo sapiens (Human)) | BDBM50437505
(CHEMBL2409778)Show SMILES Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)ccc2F)n(C)n1 Show InChI InChI=1S/C22H20FN7O3/c1-12-9-18(29(2)27-12)21(32)24-17-10-14(5-7-16(17)23)33-15-6-8-19-25-22(28-30(19)11-15)26-20(31)13-3-4-13/h5-11,13H,3-4H2,1-2H3,(H,24,32)(H,26,28,31) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description Inhibition of IR (unknown origin) using biotinylated poly-GluTyr as substrate by AlphaScreen assay |
Bioorg Med Chem 21: 4714-29 (2013)
Article DOI: 10.1016/j.bmc.2013.04.042 BindingDB Entry DOI: 10.7270/Q2ZS2XZQ |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor alpha
(Homo sapiens (Human)) | BDBM50437505
(CHEMBL2409778)Show SMILES Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)ccc2F)n(C)n1 Show InChI InChI=1S/C22H20FN7O3/c1-12-9-18(29(2)27-12)21(32)24-17-10-14(5-7-16(17)23)33-15-6-8-19-25-22(28-30(19)11-15)26-20(31)13-3-4-13/h5-11,13H,3-4H2,1-2H3,(H,24,32)(H,26,28,31) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description Inhibition of PDGFRalpha (unknown origin) using biotinylated poly-GluTyr as substrate by AlphaScreen assay |
Bioorg Med Chem 21: 4714-29 (2013)
Article DOI: 10.1016/j.bmc.2013.04.042 BindingDB Entry DOI: 10.7270/Q2ZS2XZQ |
More data for this Ligand-Target Pair | |
Aurora kinase A
(Homo sapiens (Human)) | BDBM50437505
(CHEMBL2409778)Show SMILES Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)ccc2F)n(C)n1 Show InChI InChI=1S/C22H20FN7O3/c1-12-9-18(29(2)27-12)21(32)24-17-10-14(5-7-16(17)23)33-15-6-8-19-25-22(28-30(19)11-15)26-20(31)13-3-4-13/h5-11,13H,3-4H2,1-2H3,(H,24,32)(H,26,28,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description Inhibition of aurora A (unknown origin) in presence of [gamma-33P]-ATP |
Bioorg Med Chem 21: 4714-29 (2013)
Article DOI: 10.1016/j.bmc.2013.04.042 BindingDB Entry DOI: 10.7270/Q2ZS2XZQ |
More data for this Ligand-Target Pair | |
Aurora kinase A
(Homo sapiens (Human)) | BDBM50437505
(CHEMBL2409778)Show SMILES Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)ccc2F)n(C)n1 Show InChI InChI=1S/C22H20FN7O3/c1-12-9-18(29(2)27-12)21(32)24-17-10-14(5-7-16(17)23)33-15-6-8-19-25-22(28-30(19)11-15)26-20(31)13-3-4-13/h5-11,13H,3-4H2,1-2H3,(H,24,32)(H,26,28,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description Inhibition of aurora A (unknown origin) in presence of [gamma-33P]-ATP |
Bioorg Med Chem 21: 4714-29 (2013)
Article DOI: 10.1016/j.bmc.2013.04.042 BindingDB Entry DOI: 10.7270/Q2ZS2XZQ |
More data for this Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50437505
(CHEMBL2409778)Show SMILES Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)ccc2F)n(C)n1 Show InChI InChI=1S/C22H20FN7O3/c1-12-9-18(29(2)27-12)21(32)24-17-10-14(5-7-16(17)23)33-15-6-8-19-25-22(28-30(19)11-15)26-20(31)13-3-4-13/h5-11,13H,3-4H2,1-2H3,(H,24,32)(H,26,28,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description Inhibition of PDGFRbeta (unknown origin) using biotinylated poly-GluTyr as substrate preincubated for 5 mins followed by ATP addition by AlphaScreen ... |
Bioorg Med Chem 21: 4714-29 (2013)
Article DOI: 10.1016/j.bmc.2013.04.042 BindingDB Entry DOI: 10.7270/Q2ZS2XZQ |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase B-raf
(Homo sapiens (Human)) | BDBM50437505
(CHEMBL2409778)Show SMILES Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)nn4c3)ccc2F)n(C)n1 Show InChI InChI=1S/C22H20FN7O3/c1-12-9-18(29(2)27-12)21(32)24-17-10-14(5-7-16(17)23)33-15-6-8-19-25-22(28-30(19)11-15)26-20(31)13-3-4-13/h5-11,13H,3-4H2,1-2H3,(H,24,32)(H,26,28,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd
Curated by ChEMBL
| Assay Description Inhibition of B-raf (unknown origin) in presence of [gamma-33P]-ATP |
Bioorg Med Chem 21: 4714-29 (2013)
Article DOI: 10.1016/j.bmc.2013.04.042 BindingDB Entry DOI: 10.7270/Q2ZS2XZQ |
More data for this Ligand-Target Pair | |