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BDBM50437844 CHEMBL2407896

SMILES: O=C1Nc2ccccc2\C1=C/c1ccc2c(\C=C\c3ccccc3)n[nH]c2c1

InChI Key: InChIKey=YJKHNFBXHIHRMJ-WRMRRPGHSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50437844   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PLK3


(Homo sapiens (Human))
BDBM50437844
PNG
(CHEMBL2407896)
Show SMILES O=C1Nc2ccccc2\C1=C/c1ccc2c(\C=C\c3ccccc3)n[nH]c2c1
Show InChI InChI=1S/C24H17N3O/c28-24-20(18-8-4-5-9-21(18)25-24)14-17-10-12-19-22(26-27-23(19)15-17)13-11-16-6-2-1-3-7-16/h1-15H,(H,25,28)(H,26,27)/b13-11+,20-14+
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



EntreMed Inc.

Curated by ChEMBL


Assay Description
Inhibition of PLK3 (unknown origin) by FRET-based homogeneous assay


J Med Chem 56: 6069-87 (2013)


Article DOI: 10.1021/jm400380m
BindingDB Entry DOI: 10.7270/Q2HM59V9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM50437844
PNG
(CHEMBL2407896)
Show SMILES O=C1Nc2ccccc2\C1=C/c1ccc2c(\C=C\c3ccccc3)n[nH]c2c1
Show InChI InChI=1S/C24H17N3O/c28-24-20(18-8-4-5-9-21(18)25-24)14-17-10-12-19-22(26-27-23(19)15-17)13-11-16-6-2-1-3-7-16/h1-15H,(H,25,28)(H,26,27)/b13-11+,20-14+
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 42n/an/an/an/an/an/a



EntreMed Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human PLK4 (1 to 391 amino acids) expressed in Escherichia coli using TMB as substrate after 30 mins by indirect ...


J Med Chem 56: 6069-87 (2013)


Article DOI: 10.1021/jm400380m
BindingDB Entry DOI: 10.7270/Q2HM59V9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50437844
PNG
(CHEMBL2407896)
Show SMILES O=C1Nc2ccccc2\C1=C/c1ccc2c(\C=C\c3ccccc3)n[nH]c2c1
Show InChI InChI=1S/C24H17N3O/c28-24-20(18-8-4-5-9-21(18)25-24)14-17-10-12-19-22(26-27-23(19)15-17)13-11-16-6-2-1-3-7-16/h1-15H,(H,25,28)(H,26,27)/b13-11+,20-14+
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



EntreMed Inc.

Curated by ChEMBL


Assay Description
Inhibition of PLK1 (unknown origin) by FRET-based homogeneous assay


J Med Chem 56: 6069-87 (2013)


Article DOI: 10.1021/jm400380m
BindingDB Entry DOI: 10.7270/Q2HM59V9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK2


(Homo sapiens (Human))
BDBM50437844
PNG
(CHEMBL2407896)
Show SMILES O=C1Nc2ccccc2\C1=C/c1ccc2c(\C=C\c3ccccc3)n[nH]c2c1
Show InChI InChI=1S/C24H17N3O/c28-24-20(18-8-4-5-9-21(18)25-24)14-17-10-12-19-22(26-27-23(19)15-17)13-11-16-6-2-1-3-7-16/h1-15H,(H,25,28)(H,26,27)/b13-11+,20-14+
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



EntreMed Inc.

Curated by ChEMBL


Assay Description
Inhibition of PLK2 (unknown origin) by FRET-based homogeneous assay


J Med Chem 56: 6069-87 (2013)


Article DOI: 10.1021/jm400380m
BindingDB Entry DOI: 10.7270/Q2HM59V9
More data for this
Ligand-Target Pair