BDBM50437854 CHEMBL2407918

SMILES: CC(=O)Nc1ccc2NC(=O)\C(=C\c3ccc4cn[nH]c4c3)c2c1

InChI Key: InChIKey=UXFLFGRXPDAOOG-GIDUJCDVSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50437854   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase PLK3 (Homo sapiens (Human))	BDBM50437854 (CHEMBL2407918) Show SMILES CC(=O)Nc1ccc2NC(=O)\C(=C\c3ccc4cn[nH]c4c3)c2c1 Show InChI InChI=1S/C18H14N4O2/c1-10(23)20-13-4-5-16-14(8-13)15(18(24)21-16)6-11-2-3-12-9-19-22-17(12)7-11/h2-9H,1H3,(H,19,22)(H,20,23)(H,21,24)/b15-6+	PDB NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
EntreMed Inc. Curated by ChEMBL					Assay Description Inhibition of PLK3 (unknown origin) by FRET-based homogeneous assay				J Med Chem 56: 6069-87 (2013) Article DOI: 10.1021/jm400380m BindingDB Entry DOI: 10.7270/Q2HM59V9
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK4 (Homo sapiens (Human))	BDBM50437854 (CHEMBL2407918) Show SMILES CC(=O)Nc1ccc2NC(=O)\C(=C\c3ccc4cn[nH]c4c3)c2c1 Show InChI InChI=1S/C18H14N4O2/c1-10(23)20-13-4-5-16-14(8-13)15(18(24)21-16)6-11-2-3-12-9-19-22-17(12)7-11/h2-9H,1H3,(H,19,22)(H,20,23)(H,21,24)/b15-6+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
EntreMed Inc. Curated by ChEMBL					Assay Description Inhibition of N-terminal GST-tagged human PLK4 (1 to 391 amino acids) expressed in Escherichia coli using TMB as substrate after 30 mins by indirect ...				J Med Chem 56: 6069-87 (2013) Article DOI: 10.1021/jm400380m BindingDB Entry DOI: 10.7270/Q2HM59V9
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50437854 (CHEMBL2407918) Show SMILES CC(=O)Nc1ccc2NC(=O)\C(=C\c3ccc4cn[nH]c4c3)c2c1 Show InChI InChI=1S/C18H14N4O2/c1-10(23)20-13-4-5-16-14(8-13)15(18(24)21-16)6-11-2-3-12-9-19-22-17(12)7-11/h2-9H,1H3,(H,19,22)(H,20,23)(H,21,24)/b15-6+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
EntreMed Inc. Curated by ChEMBL					Assay Description Inhibition of PLK1 (unknown origin) by FRET-based homogeneous assay				J Med Chem 56: 6069-87 (2013) Article DOI: 10.1021/jm400380m BindingDB Entry DOI: 10.7270/Q2HM59V9
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PLK2 (Homo sapiens (Human))	BDBM50437854 (CHEMBL2407918) Show SMILES CC(=O)Nc1ccc2NC(=O)\C(=C\c3ccc4cn[nH]c4c3)c2c1 Show InChI InChI=1S/C18H14N4O2/c1-10(23)20-13-4-5-16-14(8-13)15(18(24)21-16)6-11-2-3-12-9-19-22-17(12)7-11/h2-9H,1H3,(H,19,22)(H,20,23)(H,21,24)/b15-6+	PDB NCI pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
EntreMed Inc. Curated by ChEMBL					Assay Description Inhibition of PLK2 (unknown origin) by FRET-based homogeneous assay				J Med Chem 56: 6069-87 (2013) Article DOI: 10.1021/jm400380m BindingDB Entry DOI: 10.7270/Q2HM59V9
					More data for this Ligand-Target Pair