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BDBM50437858 CHEMBL2407910

SMILES: O=C1Nc2ccccc2\C1=C\c1ccc2[nH]ncc2c1

InChI Key: InChIKey=HKGXDXUDOHQKPM-JYRVWZFOSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50437858   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PLK3


(Homo sapiens (Human))
BDBM50437858
PNG
(CHEMBL2407910)
Show SMILES O=C1Nc2ccccc2\C1=C\c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C16H11N3O/c20-16-13(12-3-1-2-4-15(12)18-16)8-10-5-6-14-11(7-10)9-17-19-14/h1-9H,(H,17,19)(H,18,20)/b13-8-
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.10E+4n/an/an/an/an/an/a



EntreMed Inc.

Curated by ChEMBL


Assay Description
Inhibition of PLK3 (unknown origin) by FRET-based homogeneous assay


J Med Chem 56: 6069-87 (2013)


Article DOI: 10.1021/jm400380m
BindingDB Entry DOI: 10.7270/Q2HM59V9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK4


(Homo sapiens (Human))
BDBM50437858
PNG
(CHEMBL2407910)
Show SMILES O=C1Nc2ccccc2\C1=C\c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C16H11N3O/c20-16-13(12-3-1-2-4-15(12)18-16)8-10-5-6-14-11(7-10)9-17-19-14/h1-9H,(H,17,19)(H,18,20)/b13-8-
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 390n/an/an/an/an/an/a



EntreMed Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human PLK4 (1 to 391 amino acids) expressed in Escherichia coli using TMB as substrate after 30 mins by indirect ...


J Med Chem 56: 6069-87 (2013)


Article DOI: 10.1021/jm400380m
BindingDB Entry DOI: 10.7270/Q2HM59V9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50437858
PNG
(CHEMBL2407910)
Show SMILES O=C1Nc2ccccc2\C1=C\c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C16H11N3O/c20-16-13(12-3-1-2-4-15(12)18-16)8-10-5-6-14-11(7-10)9-17-19-14/h1-9H,(H,17,19)(H,18,20)/b13-8-
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.00E+4n/an/an/an/an/an/a



EntreMed Inc.

Curated by ChEMBL


Assay Description
Inhibition of PLK1 (unknown origin) by FRET-based homogeneous assay


J Med Chem 56: 6069-87 (2013)


Article DOI: 10.1021/jm400380m
BindingDB Entry DOI: 10.7270/Q2HM59V9
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK2


(Homo sapiens (Human))
BDBM50437858
PNG
(CHEMBL2407910)
Show SMILES O=C1Nc2ccccc2\C1=C\c1ccc2[nH]ncc2c1
Show InChI InChI=1S/C16H11N3O/c20-16-13(12-3-1-2-4-15(12)18-16)8-10-5-6-14-11(7-10)9-17-19-14/h1-9H,(H,17,19)(H,18,20)/b13-8-
PDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.90E+3n/an/an/an/an/an/a



EntreMed Inc.

Curated by ChEMBL


Assay Description
Inhibition of PLK2 (unknown origin) by FRET-based homogeneous assay


J Med Chem 56: 6069-87 (2013)


Article DOI: 10.1021/jm400380m
BindingDB Entry DOI: 10.7270/Q2HM59V9
More data for this
Ligand-Target Pair