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BDBM50437986 CHEMBL2409103

SMILES: FC(F)(F)c1cccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CCC2)c1

InChI Key: InChIKey=HWFDNIKGXJLHGC-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50437986   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50437986
PNG
(CHEMBL2409103)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CCC2)c1
Show InChI InChI=1S/C21H19F3N4O/c22-21(23,24)15-8-5-9-16(12-15)25-20(29)26-19-13-18(14-6-4-7-14)27-28(19)17-10-2-1-3-11-17/h1-3,5,8-14H,4,6-7H2,(H2,25,26,29)
PDB
MMDB

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UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.30E+3n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/2 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM50437986
PNG
(CHEMBL2409103)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CCC2)c1
Show InChI InChI=1S/C21H19F3N4O/c22-21(23,24)15-8-5-9-16(12-15)25-20(29)26-19-13-18(14-6-4-7-14)27-28(19)17-10-2-1-3-11-17/h1-3,5,8-14H,4,6-7H2,(H2,25,26,29)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 690n/an/an/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Inhibition of GIRK1/4 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN
More data for this
Ligand-Target Pair