BDBM50440109 CHEMBL2426109

SMILES: CC(CNC(=O)CC(F)(F)F)[C@@H](c1ccccc1)c1ccc2n(ncc2c1)-c1ccc(F)cc1

InChI Key: InChIKey=ONJOAXGRGNHUGJ-HHPDBAQJSA-N

Data: 2 KI  4 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50440109   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50440109 (CHEMBL2426109) Show SMILES CC(CNC(=O)CC(F)(F)F)[C@@H](c1ccccc1)c1ccc2n(ncc2c1)-c1ccc(F)cc1 |r| Show InChI InChI=1S/C26H23F4N3O/c1-17(15-31-24(34)14-26(28,29)30)25(18-5-3-2-4-6-18)19-7-12-23-20(13-19)16-32-33(23)22-10-8-21(27)9-11-22/h2-13,16-17,25H,14-15H2,1H3,(H,31,34)/t17?,25-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence assay				Bioorg Med Chem Lett 23: 5448-51 (2013) Article DOI: 10.1016/j.bmcl.2013.06.085 BindingDB Entry DOI: 10.7270/Q22R3T2S
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50440109 (CHEMBL2426109) Show SMILES CC(CNC(=O)CC(F)(F)F)[C@@H](c1ccccc1)c1ccc2n(ncc2c1)-c1ccc(F)cc1 |r| Show InChI InChI=1S/C26H23F4N3O/c1-17(15-31-24(34)14-26(28,29)30)25(18-5-3-2-4-6-18)19-7-12-23-20(13-19)16-32-33(23)22-10-8-21(27)9-11-22/h2-13,16-17,25H,14-15H2,1H3,(H,31,34)/t17?,25-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Binding affinity to glucocorticoid receptor (unknown origin) by fluorescence assay				Bioorg Med Chem Lett 23: 5448-51 (2013) Article DOI: 10.1016/j.bmcl.2013.06.085 BindingDB Entry DOI: 10.7270/Q22R3T2S
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50440109 (CHEMBL2426109) Show SMILES CC(CNC(=O)CC(F)(F)F)[C@@H](c1ccccc1)c1ccc2n(ncc2c1)-c1ccc(F)cc1 |r| Show InChI InChI=1S/C26H23F4N3O/c1-17(15-31-24(34)14-26(28,29)30)25(18-5-3-2-4-6-18)19-7-12-23-20(13-19)16-32-33(23)22-10-8-21(27)9-11-22/h2-13,16-17,25H,14-15H2,1H3,(H,31,34)/t17?,25-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	52	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Transrepression activity at glucocorticoid receptor in human A549 cells assessed as inhibition of PMA-stimulated AP1 response element by luciferase r...				Bioorg Med Chem Lett 23: 5448-51 (2013) Article DOI: 10.1016/j.bmcl.2013.06.085 BindingDB Entry DOI: 10.7270/Q22R3T2S
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50440109 (CHEMBL2426109) Show SMILES CC(CNC(=O)CC(F)(F)F)[C@@H](c1ccccc1)c1ccc2n(ncc2c1)-c1ccc(F)cc1 |r| Show InChI InChI=1S/C26H23F4N3O/c1-17(15-31-24(34)14-26(28,29)30)25(18-5-3-2-4-6-18)19-7-12-23-20(13-19)16-32-33(23)22-10-8-21(27)9-11-22/h2-13,16-17,25H,14-15H2,1H3,(H,31,34)/t17?,25-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	374	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Transactivation activity at glucocorticoid receptor ligand binding domain (unknown origin) expressed in human Hela cells co-expressing GAL4 DNA bindi...				Bioorg Med Chem Lett 23: 5448-51 (2013) Article DOI: 10.1016/j.bmcl.2013.06.085 BindingDB Entry DOI: 10.7270/Q22R3T2S
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50440109 (CHEMBL2426109) Show SMILES CC(CNC(=O)CC(F)(F)F)[C@@H](c1ccccc1)c1ccc2n(ncc2c1)-c1ccc(F)cc1 |r| Show InChI InChI=1S/C26H23F4N3O/c1-17(15-31-24(34)14-26(28,29)30)25(18-5-3-2-4-6-18)19-7-12-23-20(13-19)16-32-33(23)22-10-8-21(27)9-11-22/h2-13,16-17,25H,14-15H2,1H3,(H,31,34)/t17?,25-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	21	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Transactivation activity at glucocorticoid receptor ligand binding domain (unknown origin) expressed in human Hela cells co-expressing GAL4 DNA bindi...				Bioorg Med Chem Lett 23: 5448-51 (2013) Article DOI: 10.1016/j.bmcl.2013.06.085 BindingDB Entry DOI: 10.7270/Q22R3T2S
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50440109 (CHEMBL2426109) Show SMILES CC(CNC(=O)CC(F)(F)F)[C@@H](c1ccccc1)c1ccc2n(ncc2c1)-c1ccc(F)cc1 |r| Show InChI InChI=1S/C26H23F4N3O/c1-17(15-31-24(34)14-26(28,29)30)25(18-5-3-2-4-6-18)19-7-12-23-20(13-19)16-32-33(23)22-10-8-21(27)9-11-22/h2-13,16-17,25H,14-15H2,1H3,(H,31,34)/t17?,25-/m0/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7.5	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company Curated by ChEMBL					Assay Description Transrepression activity at glucocorticoid receptor in human A549 cells assessed as inhibition of PMA-stimulated AP1 response element by luciferase r...				Bioorg Med Chem Lett 23: 5448-51 (2013) Article DOI: 10.1016/j.bmcl.2013.06.085 BindingDB Entry DOI: 10.7270/Q22R3T2S
					More data for this Ligand-Target Pair