BindingDB PrimarySearch

BDBM50440614 CHEMBL2426364

SMILES: O=C(N1CCC(CC1)N1CCCC1)c1ccc(C(=O)N2CCC(CC2)N2CCCC2)c(Nc2ccccc2)c1

InChI Key: InChIKey=PQOOIERVZAXHBP-UHFFFAOYSA-N

Data: 19 IC50 3 Kd

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50440614
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Scm-like with four MBT domains protein 1 (Homo sapiens (Human))	BDBM50440614 (CHEMBL2426364) Show SMILES Show InChI	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill Curated by ChEMBL					Assay Description Inhibition of SFMBT1 (unknown origin) after 30 mins by AlphaScreen assay				J Med Chem 56: 7358-71 (2013) Article DOI: 10.1021/jm400919p BindingDB Entry DOI: 10.7270/Q2B27WRP
					More data for this Ligand-Target Pair
Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3) (Homo sapiens (Human))	BDBM50440614 (CHEMBL2426364) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					Assay Description Inhibition of L3MBTL3 (unknown origin) assessed as dissociation constant by isothermal titration calorimetry				J Med Chem 62: 8996-9007 (2019) Article DOI: 10.1021/acs.jmedchem.9b00522
Icahn School of Medicine at Mount Sinai Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
PHD finger protein 23 (PHF23) (Homo sapiens (Human))	BDBM50440614 (CHEMBL2426364) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill Curated by ChEMBL					Assay Description Inhibition of PHF23 (unknown origin) after 30 mins by AlphaScreen assay				J Med Chem 56: 7358-71 (2013) Article DOI: 10.1021/jm400919p BindingDB Entry DOI: 10.7270/Q2B27WRP
					More data for this Ligand-Target Pair
Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3) (Homo sapiens (Human))	BDBM50440614 (CHEMBL2426364) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	64	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill Curated by ChEMBL					Assay Description Inhibition of L3MBTL3 (unknown origin) after 30 mins by AlphaScreen assay				J Med Chem 56: 7358-71 (2013) Article DOI: 10.1021/jm400919p BindingDB Entry DOI: 10.7270/Q2B27WRP
					More data for this Ligand-Target Pair				3D Structure (crystal)
Lethal(3)malignant brain tumor-like protein 4 (Homo sapiens (Human))	BDBM50440614 (CHEMBL2426364) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill Curated by ChEMBL					Assay Description Inhibition of L3MBTL4 (unknown origin) after 30 mins by AlphaScreen assay				J Med Chem 56: 7358-71 (2013) Article DOI: 10.1021/jm400919p BindingDB Entry DOI: 10.7270/Q2B27WRP
					More data for this Ligand-Target Pair
Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1) (Homo sapiens (Human))	BDBM50440614 (CHEMBL2426364) Show SMILES Show InChI	PDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	9.40E+3	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill Curated by ChEMBL					Assay Description Binding affinity to L3MBTL1 (unknown origin) by isothermal titration calorimetric assay				J Med Chem 56: 7358-71 (2013) Article DOI: 10.1021/jm400919p BindingDB Entry DOI: 10.7270/Q2B27WRP
					More data for this Ligand-Target Pair
Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3) (Homo sapiens (Human))	BDBM50440614 (CHEMBL2426364) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill Curated by ChEMBL					Assay Description Binding affinity to L3MBTL3 (unknown origin) by isothermal titration calorimetric assay				J Med Chem 56: 7358-71 (2013) Article DOI: 10.1021/jm400919p BindingDB Entry DOI: 10.7270/Q2B27WRP
					More data for this Ligand-Target Pair				3D Structure (crystal)
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM50440614 (CHEMBL2426364) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill Curated by ChEMBL					Assay Description Inhibition of JARID1A (unknown origin) after 30 mins by AlphaScreen assay				J Med Chem 56: 7358-71 (2013) Article DOI: 10.1021/jm400919p BindingDB Entry DOI: 10.7270/Q2B27WRP
					More data for this Ligand-Target Pair
Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1) (Homo sapiens (Human))	BDBM50440614 (CHEMBL2426364) Show SMILES Show InChI	PDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill Curated by ChEMBL					Assay Description Inhibition of L3MBTL1 (unknown origin) after 30 mins by AlphaScreen assay				J Med Chem 56: 7358-71 (2013) Article DOI: 10.1021/jm400919p BindingDB Entry DOI: 10.7270/Q2B27WRP
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase (UHRF1) (Homo sapiens (Human))	BDBM50440614 (CHEMBL2426364) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill Curated by ChEMBL					Assay Description Inhibition of UHRF1 (unknown origin) after 30 mins by AlphaScreen assay				J Med Chem 56: 7358-71 (2013) Article DOI: 10.1021/jm400919p BindingDB Entry DOI: 10.7270/Q2B27WRP
					More data for this Ligand-Target Pair
Tumor suppressor p53-binding protein 1 (Homo sapiens (Human))	BDBM50440614 (CHEMBL2426364) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill Curated by ChEMBL					Assay Description Inhibition of 53BP1 (unknown origin) after 30 mins by AlphaScreen assay				J Med Chem 56: 7358-71 (2013) Article DOI: 10.1021/jm400919p BindingDB Entry DOI: 10.7270/Q2B27WRP
					More data for this Ligand-Target Pair
Chromobox protein homolog 7 (CBX7) (Homo sapiens (Human))	BDBM50440614 (CHEMBL2426364) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill Curated by ChEMBL					Assay Description Inhibition of CBX7 (unknown origin) after 30 mins by AlphaScreen assay				J Med Chem 56: 7358-71 (2013) Article DOI: 10.1021/jm400919p BindingDB Entry DOI: 10.7270/Q2B27WRP
					More data for this Ligand-Target Pair
MBT domain-containing protein 1 (MBTD1) (Homo sapiens (Human))	BDBM50440614 (CHEMBL2426364) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill Curated by ChEMBL					Assay Description Inhibition of MBTD1 (unknown origin) after 30 mins by AlphaScreen assay				J Med Chem 56: 7358-71 (2013) Article DOI: 10.1021/jm400919p BindingDB Entry DOI: 10.7270/Q2B27WRP
					More data for this Ligand-Target Pair
Lethal(3)malignant brain tumor-like protein 1 (Homo sapiens)	BDBM50440614 (CHEMBL2426364) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	8.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Inhibition of His-tagged L3MBTL1 (unknown origin) using H4K20Me1 as substrate incubated for 30 mins at room temperature followed by incubation under ...				Medchemcomm 4: 1501-1507 (2013) Article DOI: 10.1039/c3md00197k BindingDB Entry DOI: 10.7270/Q2BV7KKN
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3) (Homo sapiens (Human))	BDBM50440614 (CHEMBL2426364) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Inhibition of His-tagged L3MBTL3 (unknown origin) using H4K20Me2 as substrate incubated for 30 mins at room temperature followed by incubation under ...				Medchemcomm 4: 1501-1507 (2013) Article DOI: 10.1039/c3md00197k BindingDB Entry DOI: 10.7270/Q2BV7KKN
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
E3 ubiquitin-protein ligase (UHRF1) (Homo sapiens (Human))	BDBM50440614 (CHEMBL2426364) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Inhibition of UHRF1 tandem tudor domain (121 to 286) (unknown origin) expressed in Escherichia coli BL21 Rosetta DE3 using H3K9Me3 as substrate incub...				Medchemcomm 4: 1501-1507 (2013) Article DOI: 10.1039/c3md00197k BindingDB Entry DOI: 10.7270/Q2BV7KKN
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
Chromobox protein homolog 7 (Homo sapiens (Human))	BDBM50440614 (CHEMBL2426364) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Inhibition of CBX7 (8 to 62) (unknown origin) expressed in Escherichia coli BL21 Rosetta DE3 using H3K9Me3 as substrate incubated for 30 mins at room...				Medchemcomm 4: 1501-1507 (2013) Article DOI: 10.1039/c3md00197k BindingDB Entry DOI: 10.7270/Q2BV7KKN
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
Tumor suppressor p53-binding protein 1 (Homo sapiens (Human))	BDBM50440614 (CHEMBL2426364) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.37E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Inhibition of 53BP1 (1485 to 1611) (unknown origin) expressed in Escherichia coli BL21 Rosetta DE3 using H4K20Me2 as substrate incubated for 30 mins ...				Medchemcomm 4: 1501-1507 (2013) Article DOI: 10.1039/c3md00197k BindingDB Entry DOI: 10.7270/Q2BV7KKN
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
MBT domain-containing protein 1 (MBTD1) (Homo sapiens (Human))	BDBM50440614 (CHEMBL2426364) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	7.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Inhibition of MBTD1 (130 to 566) (unknown origin) expressed in Escherichia coli BL21 Rosetta DE3 using H4K20Me1 as substrate incubated for 30 mins at...				Medchemcomm 4: 1501-1507 (2013) Article DOI: 10.1039/c3md00197k BindingDB Entry DOI: 10.7270/Q2BV7KKN
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
PHD finger protein 23 (PHF23) (Homo sapiens (Human))	BDBM50440614 (CHEMBL2426364) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Inhibition of GST-tagged PHF23 (unknown origin) using H3K4Me3 as substrate incubated for 30 mins at room temperature followed by incubation under dar...				Medchemcomm 4: 1501-1507 (2013) Article DOI: 10.1039/c3md00197k BindingDB Entry DOI: 10.7270/Q2BV7KKN
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM50440614 (CHEMBL2426364) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Inhibition of GST-tagged Jarid1A (unknown origin) using H3K4Me3 as substrate incubated for 30 mins at room temperature followed by incubation under d...				Medchemcomm 4: 1501-1507 (2013) Article DOI: 10.1039/c3md00197k BindingDB Entry DOI: 10.7270/Q2BV7KKN
University of North Carolina Curated by ChEMBL					More data for this Ligand-Target Pair
Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3) (Homo sapiens (Human))	BDBM50440614 (CHEMBL2426364) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill Curated by ChEMBL					Assay Description Inhibition of L3MBTL3 (unknown origin) using H4K20me2 as substrate after 30 mins by LNCE-TR-FRET assay				J Med Chem 56: 7358-71 (2013) Article DOI: 10.1021/jm400919p BindingDB Entry DOI: 10.7270/Q2B27WRP
					More data for this Ligand-Target Pair				3D Structure (crystal)