BDBM50440890 CHEMBL2431841::US9066954, 341
SMILES: Cn1cc(cn1)-c1ccc2nnc(Cc3ccc4ncccc4c3)n2n1
InChI Key: InChIKey=NSNLFHBIYLDZLA-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM50440890 (CHEMBL2431841 | US9066954, 341) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 9.10 | -11.0 | n/a | n/a | n/a | n/a | n/a | 8.0 | 27 |
Amgen Inc. US Patent | Assay Description A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri... | US Patent US9066954 (2015) BindingDB Entry DOI: 10.7270/Q2N878JD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM50440890 (CHEMBL2431841 | US9066954, 341) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 74 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of N-terminal His-6-tagged human recombinant c-Met (974 to 1390) using Ac-ARDMYDKEYYSVHNK as substrate by spectrophotometric assay | J Med Chem 56: 6651-65 (2013) Article DOI: 10.1021/jm400926x BindingDB Entry DOI: 10.7270/Q2HM59WR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM50440890 (CHEMBL2431841 | US9066954, 341) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA | J Med Chem 56: 6651-65 (2013) Article DOI: 10.1021/jm400926x BindingDB Entry DOI: 10.7270/Q2HM59WR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM50440890 (CHEMBL2431841 | US9066954, 341) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
Hutchison MediPharma Limited Curated by ChEMBL | Assay Description Inhibition of c-Met (unknown origin) using Poly E4Y substrate and ATP incubated for 45 mins by fluorescence polarization assay | J Med Chem 57: 7577-89 (2014) Article DOI: 10.1021/jm500510f BindingDB Entry DOI: 10.7270/Q2JD4ZCR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM50440890 (CHEMBL2431841 | US9066954, 341) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | n/a |
Hutchison MediPharma Limited Curated by ChEMBL | Assay Description Inhibition of c-Met autophosphorylation in human NCI-H441 cells for 1 hr by ELISA | J Med Chem 57: 7577-89 (2014) Article DOI: 10.1021/jm500510f BindingDB Entry DOI: 10.7270/Q2JD4ZCR | |||||||||||
More data for this Ligand-Target Pair |