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SMILES: OC1CC2(CCN(CC2)C(=O)Nc2ccc(cc2)C(F)(F)F)Oc2c(F)cccc12

InChI Key: InChIKey=KIZOHGMVJGYGDL-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50442412   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50442412
PNG
(CHEMBL2443072)
Show SMILES OC1CC2(CCN(CC2)C(=O)Nc2ccc(cc2)C(F)(F)F)Oc2c(F)cccc12
Show InChI InChI=1S/C21H20F4N2O3/c22-16-3-1-2-15-17(28)12-20(30-18(15)16)8-10-27(11-9-20)19(29)26-14-6-4-13(5-7-14)21(23,24)25/h1-7,17,28H,8-12H2,(H,26,29)
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Article
PubMed
n/an/a 90n/an/an/an/an/an/a



Glenmark Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced 45Ca2+ uptake incubated for 10 mins prior to icili...

Bioorg Med Chem 21: 6542-53 (2013)


Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S
More data for this
Ligand-Target Pair