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SMILES: FC(F)(F)c1ccc(NC(=O)N2CCC3(CC2)CCc2cccc(Br)c2O3)cc1

InChI Key: InChIKey=SWWVNWXXFFDOKL-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50442426   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily M member 8


(Homo sapiens (Human))		BDBM50442426
PNG
(CHEMBL2443085)
Show SMILES FC(F)(F)c1ccc(NC(=O)N2CCC3(CC2)CCc2cccc(Br)c2O3)cc1
Show InChI InChI=1S/C21H20BrF3N2O2/c22-17-3-1-2-14-8-9-20(29-18(14)17)10-12-27(13-11-20)19(28)26-16-6-4-15(5-7-16)21(23,24)25/h1-7H,8-13H2,(H,26,28)
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Article
PubMed
n/an/a 19n/an/an/an/an/an/a



Glenmark Pharmaceuticals Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced 45Ca2+ uptake incubated for 10 mins prior to icili...

Bioorg Med Chem 21: 6542-53 (2013)


Article DOI: 10.1016/j.bmc.2013.08.031
BindingDB Entry DOI: 10.7270/Q2TH8P5S
More data for this
Ligand-Target Pair