BDBM50442610 CHEMBL2441428

SMILES: Clc1cc(CCN2CCN(CC2)C(=O)Cc2ccc(cc2)-n2cnnn2)cc2COC(=O)c12

InChI Key: InChIKey=LXARJHMGHFCGNE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50442610   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM50442610 (CHEMBL2441428) Show SMILES Clc1cc(CCN2CCN(CC2)C(=O)Cc2ccc(cc2)-n2cnnn2)cc2COC(=O)c12 Show InChI InChI=1S/C23H23ClN6O3/c24-20-12-17(11-18-14-33-23(32)22(18)20)5-6-28-7-9-29(10-8-28)21(31)13-16-1-3-19(4-2-16)30-15-25-26-27-30/h1-4,11-12,15H,5-10,13-14H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	830	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human ROMK channel-mediated 86Rb+ flux expressed in CHO cells after 35 mins by scintillation counting analysis				Bioorg Med Chem Lett 23: 5829-32 (2013) Article DOI: 10.1016/j.bmcl.2013.08.104 BindingDB Entry DOI: 10.7270/Q28K7BHG
					More data for this Ligand-Target Pair