BDBM50442702 CHEMBL2442511::US9296728, 26
SMILES: OC(=O)c1cc2ccc(cc2oc1=O)N1CCCC1
InChI Key: InChIKey=AZGXIHFVKOMJRL-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Monocarboxylate transporter 1 (Rattus norvegicus (Rat)) | BDBM50442702 (CHEMBL2442511 | US9296728, 26) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 220 | n/a | n/a | n/a | n/a | 7.43 | 37 |
Regents of the University of Minnesota US Patent | Assay Description The entire lactate uptake studies for the inhibition of MCT1 were carried out on RBE4 (Rat Brain Endothelial 4) cells. The expression of MCT1 on thes... | US Patent US9296728 (2016) BindingDB Entry DOI: 10.7270/Q2KH0M5R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monocarboxylate transporter 4 (Homo sapiens (Human)) | BDBM50442702 (CHEMBL2442511 | US9296728, 26) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recherche Exp£rimentale et Clinique (IREC) Curated by ChEMBL | Assay Description Inhibition of MCT4-mediated [14C]-lactate uptake in human SiHa cells in lactate-containing medium assessed as remaining lactate concentration in cult... | Bioorg Med Chem 21: 7107-17 (2013) Article DOI: 10.1016/j.bmc.2013.09.010 BindingDB Entry DOI: 10.7270/Q2H133G8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monocarboxylate transporter 1 (Rattus norvegicus (Rat)) | BDBM50442702 (CHEMBL2442511 | US9296728, 26) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota Curated by ChEMBL | Assay Description Inhibition of MCT1 in rat brain endothelial 4 cells assessed as L-[14C]-Lactate Uptake after 15 mins by scintillation spectrometric analysis | Bioorg Med Chem Lett 26: 3282-3286 (2016) BindingDB Entry DOI: 10.7270/Q2BP04QP | |||||||||||
More data for this Ligand-Target Pair |