null
SMILES: C[C@@H](Oc1cc(cnc1N)-c1ccc2c(NC(=O)C22CCN(C)CC2)c1)c1c(Cl)ccc(F)c1Cl
InChI Key: InChIKey=PIRWRQQYRXWTII-CQSZACIVSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human)) | BDBM50443560 (CHEMBL3091723) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Southern Medical University Curated by ChEMBL | Assay Description Inhibition of full-length AXL (unknown origin) phosphorylation expressed in MEF after 90 mins by Sandwich-ELISA | ACS Med Chem Lett 4: 806-10 (2013) Article DOI: 10.1021/ml400203d BindingDB Entry DOI: 10.7270/Q2V1268J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM50443560 (CHEMBL3091723) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Southern Medical University Curated by ChEMBL | Assay Description Inhibition of NPM-fused ALK phosphorylation (unknown origin) expressed in human karpas 299 cells after 90 mins by Sandwich-ELISA | ACS Med Chem Lett 4: 806-10 (2013) Article DOI: 10.1021/ml400203d BindingDB Entry DOI: 10.7270/Q2V1268J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM50443560 (CHEMBL3091723) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Southern Medical University Curated by ChEMBL | Assay Description Inhibition of c-Met phosphorylation in human MKN845 cells after 1 hr by western blotting | ACS Med Chem Lett 4: 806-10 (2013) Article DOI: 10.1021/ml400203d BindingDB Entry DOI: 10.7270/Q2V1268J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human)) | BDBM50443560 (CHEMBL3091723) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Southern Medical University Curated by ChEMBL | Assay Description Inhibition of human AXL (unknown origin) using EAIYAAPFAKKK peptide as substrate by nanoliter kinase assay | ACS Med Chem Lett 4: 806-10 (2013) Article DOI: 10.1021/ml400203d BindingDB Entry DOI: 10.7270/Q2V1268J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM50443560 (CHEMBL3091723) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Southern Medical University Curated by ChEMBL | Assay Description Inhibition of human c-Met using KKKSPGEYVNIEFG peptide as substrate by nanoliter kinase assay | ACS Med Chem Lett 4: 806-10 (2013) Article DOI: 10.1021/ml400203d BindingDB Entry DOI: 10.7270/Q2V1268J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM50443560 (CHEMBL3091723) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Southern Medical University Curated by ChEMBL | Assay Description Inhibition of c-Met phosphorylation in human MKN845 cells after 90 mins by Sandwich-ELISA | ACS Med Chem Lett 4: 806-10 (2013) Article DOI: 10.1021/ml400203d BindingDB Entry DOI: 10.7270/Q2V1268J | |||||||||||
More data for this Ligand-Target Pair |