BDBM50443627 CHEMBL3092450::US9216998, 5

SMILES: COc1cc2CCCn3c(CCc4ccccc4)c(c(c1)c23)C(F)(F)F

InChI Key: InChIKey=MXODNNNPSJJTNP-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50443627   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Endothelial lipase (Homo sapiens (Human))	BDBM50443627 (CHEMBL3092450 | US9216998, 5) Show SMILES COc1cc2CCCn3c(CCc4ccccc4)c(c(c1)c23)C(F)(F)F Show InChI InChI=1S/C21H20F3NO/c1-26-16-12-15-8-5-11-25-18(10-9-14-6-3-2-4-7-14)19(21(22,23)24)17(13-16)20(15)25/h2-4,6-7,12-13H,5,8-11H2,1H3	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	US Patent	n/a	n/a	14	n/a	n/a	n/a	n/a	7.2	n/a
Janssen Pharmaceutica NV US Patent					Assay Description To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...				US Patent US9216998 (2015) BindingDB Entry DOI: 10.7270/Q22N513F
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50443627 (CHEMBL3092450 | US9216998, 5) Show SMILES COc1cc2CCCn3c(CCc4ccccc4)c(c(c1)c23)C(F)(F)F Show InChI InChI=1S/C21H20F3NO/c1-26-16-12-15-8-5-11-25-18(10-9-14-6-3-2-4-7-14)19(21(22,23)24)17(13-16)20(15)25/h2-4,6-7,12-13H,5,8-11H2,1H3	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL					Assay Description Inhibition of human endothelial lipase using PLAi as substrate measured for 30 mins by cell-based fluorescence assay				ACS Med Chem Lett 4: 1016-7 (2013) Article DOI: 10.1021/ml400361q BindingDB Entry DOI: 10.7270/Q22J6DBG
					More data for this Ligand-Target Pair
Endothelial lipase (EL) (Mus musculus (Mouse))	BDBM50443627 (CHEMBL3092450 | US9216998, 5) Show SMILES COc1cc2CCCn3c(CCc4ccccc4)c(c(c1)c23)C(F)(F)F Show InChI InChI=1S/C21H20F3NO/c1-26-16-12-15-8-5-11-25-18(10-9-14-6-3-2-4-7-14)19(21(22,23)24)17(13-16)20(15)25/h2-4,6-7,12-13H,5,8-11H2,1H3	UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL					Assay Description Inhibition of mouse endothelial lipase using PLAi as substrate measured for 30 mins by cell-based fluorescence assay				ACS Med Chem Lett 4: 1016-7 (2013) Article DOI: 10.1021/ml400361q BindingDB Entry DOI: 10.7270/Q22J6DBG
					More data for this Ligand-Target Pair
Endothelial lipase (EL) (Mus musculus (Mouse))	BDBM50443627 (CHEMBL3092450 | US9216998, 5) Show SMILES COc1cc2CCCn3c(CCc4ccccc4)c(c(c1)c23)C(F)(F)F Show InChI InChI=1S/C21H20F3NO/c1-26-16-12-15-8-5-11-25-18(10-9-14-6-3-2-4-7-14)19(21(22,23)24)17(13-16)20(15)25/h2-4,6-7,12-13H,5,8-11H2,1H3	UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	7.2	n/a
Janssen Pharmaceutica NV US Patent					Assay Description To assay for cell surface lipase activity, cells expressing human endothelial lipase (EL) or LPL were plated in CellBIND® 384-well plates (Corning, L...				US Patent US9216998 (2015) BindingDB Entry DOI: 10.7270/Q22N513F
					More data for this Ligand-Target Pair