BDBM50443892 CHEMBL3091549

SMILES: Cc1cccc(C)c1NC(=O)c1ccc(Nc2nccc(n2)-c2ccc(OC(F)(F)F)cc2)cc1

InChI Key: InChIKey=CEJDBSAMQOQPMD-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50443892   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sonic hedgehog protein (Mus musculus (Mouse))	BDBM50443892 (CHEMBL3091549) Show SMILES Cc1cccc(C)c1NC(=O)c1ccc(Nc2nccc(n2)-c2ccc(OC(F)(F)F)cc2)cc1 Show InChI InChI=1S/C26H21F3N4O2/c1-16-4-3-5-17(2)23(16)33-24(34)19-6-10-20(11-7-19)31-25-30-15-14-22(32-25)18-8-12-21(13-9-18)35-26(27,28)29/h3-15H,1-2H3,(H,33,34)(H,30,31,32)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
Jiangsu Simcere Pharmaceutical Co. Ltd Curated by ChEMBL					Assay Description Inhibition of SHH signaling pathway in mouse NIH3T3 cells measured after 48 hrs by Gli-luciferase reporter assay				Bioorg Med Chem Lett 23: 6777-83 (2013) Article DOI: 10.1016/j.bmcl.2013.10.022 BindingDB Entry DOI: 10.7270/Q2R49S7W
					More data for this Ligand-Target Pair