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SMILES: OC(=O)c1cc(ccc1N1CC[C@@H](C1)OCc1ncccc1F)C(F)(F)F

InChI Key: InChIKey=CSXBQYDHJOFYLI-LBPRGKRZSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50444140   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Endothelial lipase (Homo sapiens (Human))	BDBM50444140 (CHEMBL3093394) Show SMILES OC(=O)c1cc(ccc1N1CC[C@@H](C1)OCc1ncccc1F)C(F)(F)F |r| Show InChI InChI=1S/C18H16F4N2O3/c19-14-2-1-6-23-15(14)10-27-12-5-7-24(9-12)16-4-3-11(18(20,21)22)8-13(16)17(25)26/h1-4,6,8,12H,5,7,9-10H2,(H,25,26)/t12-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc Curated by ChEMBL					Assay Description Inhibition of human endothelial lipase using HDL as substrate assessed as release of free fatty acids preincubated for 30 mins followed by substrate ...				Bioorg Med Chem 21: 7724-34 (2013) Article DOI: 10.1016/j.bmc.2013.10.023 BindingDB Entry DOI: 10.7270/Q2P55PZ8
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50444140 (CHEMBL3093394) Show SMILES OC(=O)c1cc(ccc1N1CC[C@@H](C1)OCc1ncccc1F)C(F)(F)F |r| Show InChI InChI=1S/C18H16F4N2O3/c19-14-2-1-6-23-15(14)10-27-12-5-7-24(9-12)16-4-3-11(18(20,21)22)8-13(16)17(25)26/h1-4,6,8,12H,5,7,9-10H2,(H,25,26)/t12-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	252	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc Curated by ChEMBL					Assay Description Inhibition of recombinant human endothelial lipase using bis-BODIPY-FL C11-PC as substrate preincubated for 30 mins followed by substrate addition by...				Bioorg Med Chem 21: 7724-34 (2013) Article DOI: 10.1016/j.bmc.2013.10.023 BindingDB Entry DOI: 10.7270/Q2P55PZ8
					More data for this Ligand-Target Pair
Lipoprotein lipase (Homo sapiens (Human))	BDBM50444140 (CHEMBL3093394) Show SMILES OC(=O)c1cc(ccc1N1CC[C@@H](C1)OCc1ncccc1F)C(F)(F)F |r| Show InChI InChI=1S/C18H16F4N2O3/c19-14-2-1-6-23-15(14)10-27-12-5-7-24(9-12)16-4-3-11(18(20,21)22)8-13(16)17(25)26/h1-4,6,8,12H,5,7,9-10H2,(H,25,26)/t12-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.72E+4	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc Curated by ChEMBL					Assay Description Inhibition of recombinant human lipoprotein lipase using bis-BODIPY-FL C11-PC as substrate preincubated for 30 mins followed by substrate addition by...				Bioorg Med Chem 21: 7724-34 (2013) Article DOI: 10.1016/j.bmc.2013.10.023 BindingDB Entry DOI: 10.7270/Q2P55PZ8
					More data for this Ligand-Target Pair
Hepatic triacylglycerol lipase (Homo sapiens (Human))	BDBM50444140 (CHEMBL3093394) Show SMILES OC(=O)c1cc(ccc1N1CC[C@@H](C1)OCc1ncccc1F)C(F)(F)F |r| Show InChI InChI=1S/C18H16F4N2O3/c19-14-2-1-6-23-15(14)10-27-12-5-7-24(9-12)16-4-3-11(18(20,21)22)8-13(16)17(25)26/h1-4,6,8,12H,5,7,9-10H2,(H,25,26)/t12-/m0/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.95E+4	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc Curated by ChEMBL					Assay Description Inhibition of recombinant human hepatic lipase using bis-BODIPY-FL C11-PC as substrate preincubated for 30 mins followed by substrate addition by FEL...				Bioorg Med Chem 21: 7724-34 (2013) Article DOI: 10.1016/j.bmc.2013.10.023 BindingDB Entry DOI: 10.7270/Q2P55PZ8
					More data for this Ligand-Target Pair