BDBM50444190 CHEMBL3093447

SMILES: Cc1ccc2c(CC(NS(=O)(=O)c3c(C)cc(C)cc3C)C(F)(F)F)c[nH]c2c1

InChI Key: InChIKey=CVFDJBVNXZCLBL-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50444190   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50444190 (CHEMBL3093447) Show SMILES Cc1ccc2c(CC(NS(=O)(=O)c3c(C)cc(C)cc3C)C(F)(F)F)c[nH]c2c1 Show InChI InChI=1S/C21H23F3N2O2S/c1-12-5-6-17-16(11-25-18(17)9-12)10-19(21(22,23)24)26-29(27,28)20-14(3)7-13(2)8-15(20)4/h5-9,11,19,25-26H,10H2,1-4H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Agonist activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 24 hrs				Bioorg Med Chem Lett 23: 6640-4 (2013) Article DOI: 10.1016/j.bmcl.2013.10.052 BindingDB Entry DOI: 10.7270/Q2DN46G5
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50444190 (CHEMBL3093447) Show SMILES Cc1ccc2c(CC(NS(=O)(=O)c3c(C)cc(C)cc3C)C(F)(F)F)c[nH]c2c1 Show InChI InChI=1S/C21H23F3N2O2S/c1-12-5-6-17-16(11-25-18(17)9-12)10-19(21(22,23)24)26-29(27,28)20-14(3)7-13(2)8-15(20)4/h5-9,11,19,25-26H,10H2,1-4H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Displacement of TAMRA-labeled dexamethasone from glucocorticoid receptor (unknown origin) by fluorescence polarization competitive binding assay				Bioorg Med Chem Lett 23: 6640-4 (2013) Article DOI: 10.1016/j.bmcl.2013.10.052 BindingDB Entry DOI: 10.7270/Q2DN46G5
					More data for this Ligand-Target Pair
Mineralocorticoid receptor (Homo sapiens (Human))	BDBM50444190 (CHEMBL3093447) Show SMILES Cc1ccc2c(CC(NS(=O)(=O)c3c(C)cc(C)cc3C)C(F)(F)F)c[nH]c2c1 Show InChI InChI=1S/C21H23F3N2O2S/c1-12-5-6-17-16(11-25-18(17)9-12)10-19(21(22,23)24)26-29(27,28)20-14(3)7-13(2)8-15(20)4/h5-9,11,19,25-26H,10H2,1-4H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to mineralocorticoid receptor (unknown origin) by fluorescence polarization competitive binding assay				Bioorg Med Chem Lett 23: 6640-4 (2013) Article DOI: 10.1016/j.bmcl.2013.10.052 BindingDB Entry DOI: 10.7270/Q2DN46G5
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50444190 (CHEMBL3093447) Show SMILES Cc1ccc2c(CC(NS(=O)(=O)c3c(C)cc(C)cc3C)C(F)(F)F)c[nH]c2c1 Show InChI InChI=1S/C21H23F3N2O2S/c1-12-5-6-17-16(11-25-18(17)9-12)10-19(21(22,23)24)26-29(27,28)20-14(3)7-13(2)8-15(20)4/h5-9,11,19,25-26H,10H2,1-4H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Displacement of TAMRA-labeled mifepristone from progesterone receptor (unknown origin) by fluorescence polarization competitive binding assay				Bioorg Med Chem Lett 23: 6640-4 (2013) Article DOI: 10.1016/j.bmcl.2013.10.052 BindingDB Entry DOI: 10.7270/Q2DN46G5
					More data for this Ligand-Target Pair