BDBM50444202 CHEMBL3093454

SMILES: Cc1cc(C)c(c(C)c1)S(=O)(=O)NC(Cn1ccc2ccccc12)C(F)(F)F

InChI Key: InChIKey=NXRVYSZNJVQSEI-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50444202   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50444202 (CHEMBL3093454) Show SMILES Cc1cc(C)c(c(C)c1)S(=O)(=O)NC(Cn1ccc2ccccc12)C(F)(F)F Show InChI InChI=1S/C20H21F3N2O2S/c1-13-10-14(2)19(15(3)11-13)28(26,27)24-18(20(21,22)23)12-25-9-8-16-6-4-5-7-17(16)25/h4-11,18,24H,12H2,1-3H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Agonist activity at glucocorticoid receptor in HFF assessed as inhibition of IL-1-induced IL-6 production after 24 hrs				Bioorg Med Chem Lett 23: 6640-4 (2013) Article DOI: 10.1016/j.bmcl.2013.10.052 BindingDB Entry DOI: 10.7270/Q2DN46G5
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50444202 (CHEMBL3093454) Show SMILES Cc1cc(C)c(c(C)c1)S(=O)(=O)NC(Cn1ccc2ccccc12)C(F)(F)F Show InChI InChI=1S/C20H21F3N2O2S/c1-13-10-14(2)19(15(3)11-13)28(26,27)24-18(20(21,22)23)12-25-9-8-16-6-4-5-7-17(16)25/h4-11,18,24H,12H2,1-3H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Displacement of TAMRA-labeled dexamethasone from glucocorticoid receptor (unknown origin) by fluorescence polarization competitive binding assay				Bioorg Med Chem Lett 23: 6640-4 (2013) Article DOI: 10.1016/j.bmcl.2013.10.052 BindingDB Entry DOI: 10.7270/Q2DN46G5
					More data for this Ligand-Target Pair
Mineralocorticoid receptor (Homo sapiens (Human))	BDBM50444202 (CHEMBL3093454) Show SMILES Cc1cc(C)c(c(C)c1)S(=O)(=O)NC(Cn1ccc2ccccc12)C(F)(F)F Show InChI InChI=1S/C20H21F3N2O2S/c1-13-10-14(2)19(15(3)11-13)28(26,27)24-18(20(21,22)23)12-25-9-8-16-6-4-5-7-17(16)25/h4-11,18,24H,12H2,1-3H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Binding affinity to mineralocorticoid receptor (unknown origin) by fluorescence polarization competitive binding assay				Bioorg Med Chem Lett 23: 6640-4 (2013) Article DOI: 10.1016/j.bmcl.2013.10.052 BindingDB Entry DOI: 10.7270/Q2DN46G5
					More data for this Ligand-Target Pair
Progesterone receptor (Homo sapiens (Human))	BDBM50444202 (CHEMBL3093454) Show SMILES Cc1cc(C)c(c(C)c1)S(=O)(=O)NC(Cn1ccc2ccccc12)C(F)(F)F Show InChI InChI=1S/C20H21F3N2O2S/c1-13-10-14(2)19(15(3)11-13)28(26,27)24-18(20(21,22)23)12-25-9-8-16-6-4-5-7-17(16)25/h4-11,18,24H,12H2,1-3H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Inc. Curated by ChEMBL					Assay Description Displacement of TAMRA-labeled mifepristone from progesterone receptor (unknown origin) by fluorescence polarization competitive binding assay				Bioorg Med Chem Lett 23: 6640-4 (2013) Article DOI: 10.1016/j.bmcl.2013.10.052 BindingDB Entry DOI: 10.7270/Q2DN46G5
					More data for this Ligand-Target Pair