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SMILES: O=S(=O)(c1ccc(CNC(NC#N)=Nc2ccncc2)cc1)c1ccc(nc1)N1CCOCC1

InChI Key: InChIKey=ASKVVJPLGDLWDQ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50444654   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM50444654
PNG
(CHEMBL3098517)
Show SMILES O=S(=O)(c1ccc(CNC(NC#N)=Nc2ccncc2)cc1)c1ccc(nc1)N1CCOCC1 |w:13.13|
Show InChI InChI=1S/C23H23N7O3S/c24-17-28-23(29-19-7-9-25-10-8-19)27-15-18-1-3-20(4-2-18)34(31,32)21-5-6-22(26-16-21)30-11-13-33-14-12-30/h1-10,16H,11-15H2,(H2,25,27,28,29)
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MMDB

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Article
PubMed
n/an/a 1.70n/an/an/an/an/an/a



Forma Therapeutics, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Nampt (unknown origin) using nicotinamide as substrate preincubated for 15 mins measured after 30 mins by mass spectrometry analysis

Bioorg Med Chem Lett 24: 337-43 (2013)


Article DOI: 10.1016/j.bmcl.2013.11.006
BindingDB Entry DOI: 10.7270/Q2CJ8FZH
More data for this
Ligand-Target Pair