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SMILES: OC1C2CC3CC1CC(C2)C3(Cc1nnn[nH]1)c1ccc(cc1)-c1ccccc1F

InChI Key: InChIKey=OBQOXFSFXDYXRQ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50445575   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Mus musculus (mouse))	BDBM50445575 (CHEMBL3103523) Show SMILES OC1C2CC3CC1CC(C2)C3(Cc1nnn[nH]1)c1ccc(cc1)-c1ccccc1F |TLB:0:1:10.8.7:5,9:8:5:3.2.1,1:2:10:7.6.5,1:6:10:3.9.2,17:10:5:3.2.1,11:10:3.9.2:7.6.5,THB:9:2:10.8.7:5,17:10:3.9.2:7.6.5,11:10:5:3.2.1,(34.73,-27.29,;33.44,-28.14,;33.42,-29.67,;32.02,-30.02,;30.7,-29.53,;30.69,-28.04,;32.04,-27.56,;30.99,-28.8,;31,-30.39,;32.42,-30.95,;29.5,-30.81,;28.16,-30.01,;26.81,-30.76,;25.32,-30.33,;24.46,-31.61,;25.42,-32.83,;26.87,-32.3,;29.49,-32.35,;28.15,-33.1,;28.14,-34.64,;29.47,-35.42,;30.81,-34.65,;30.81,-33.11,;29.46,-36.96,;28.12,-37.72,;28.11,-39.26,;29.44,-40.04,;30.79,-39.27,;30.79,-37.73,;32.13,-36.96,)| Show InChI InChI=1S/C24H25FN4O/c25-21-4-2-1-3-20(21)14-5-7-17(8-6-14)24(13-22-26-28-29-27-22)18-9-15-10-19(24)12-16(11-18)23(15)30/h1-8,15-16,18-19,23,30H,9-13H2,(H,26,27,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	111	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of mouse 11beta-HSD1				Bioorg Med Chem Lett 24: 654-60 (2014) Article DOI: 10.1016/j.bmcl.2013.11.066 BindingDB Entry DOI: 10.7270/Q20Z74RF
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50445575 (CHEMBL3103523) Show SMILES OC1C2CC3CC1CC(C2)C3(Cc1nnn[nH]1)c1ccc(cc1)-c1ccccc1F |TLB:0:1:10.8.7:5,9:8:5:3.2.1,1:2:10:7.6.5,1:6:10:3.9.2,17:10:5:3.2.1,11:10:3.9.2:7.6.5,THB:9:2:10.8.7:5,17:10:3.9.2:7.6.5,11:10:5:3.2.1,(34.73,-27.29,;33.44,-28.14,;33.42,-29.67,;32.02,-30.02,;30.7,-29.53,;30.69,-28.04,;32.04,-27.56,;30.99,-28.8,;31,-30.39,;32.42,-30.95,;29.5,-30.81,;28.16,-30.01,;26.81,-30.76,;25.32,-30.33,;24.46,-31.61,;25.42,-32.83,;26.87,-32.3,;29.49,-32.35,;28.15,-33.1,;28.14,-34.64,;29.47,-35.42,;30.81,-34.65,;30.81,-33.11,;29.46,-36.96,;28.12,-37.72,;28.11,-39.26,;29.44,-40.04,;30.79,-39.27,;30.79,-37.73,;32.13,-36.96,)| Show InChI InChI=1S/C24H25FN4O/c25-21-4-2-1-3-20(21)14-5-7-17(8-6-14)24(13-22-26-28-29-27-22)18-9-15-10-19(24)12-16(11-18)23(15)30/h1-8,15-16,18-19,23,30H,9-13H2,(H,26,27,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of human 11beta-HSD1				Bioorg Med Chem Lett 24: 654-60 (2014) Article DOI: 10.1016/j.bmcl.2013.11.066 BindingDB Entry DOI: 10.7270/Q20Z74RF
					More data for this Ligand-Target Pair