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BDBM50446893 CHEMBL3115307

SMILES: OC(=O)CNC(=O)c1c(O)c2cc(Cl)cnc2n(Cc2ccc(nc2)C(F)(F)F)c1=O

InChI Key: InChIKey=CYJHUVHEMIOHMC-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50446893   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50446893
PNG
(CHEMBL3115307)
Show SMILES OC(=O)CNC(=O)c1c(O)c2cc(Cl)cnc2n(Cc2ccc(nc2)C(F)(F)F)c1=O
Show InChI InChI=1S/C18H12ClF3N4O5/c19-9-3-10-14(29)13(16(30)25-6-12(27)28)17(31)26(15(10)24-5-9)7-8-1-2-11(23-4-8)18(20,21)22/h1-5,29H,6-7H2,(H,25,30)(H,27,28)
PDB
MMDB

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.650n/an/an/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of FLAG-tagged full length PHD2 (unknown origin) expressed in Sf9 cells using HIF-1alpha peptide as substrate preincubated for 30 mins fol...


J Med Chem 56: 9369-402 (2014)


Article DOI: 10.1021/jm400386j
More data for this
Ligand-Target Pair