Found 6 hits for monomerid = 50448077 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4-kinase alpha (PI4KA)
(Homo sapiens (Human)) | BDBM50448077
(CHEMBL3121308)Show SMILES COc1ncc(cc1S(=O)(=O)Nc1ccc(F)cc1F)-c1ccc2nc(N)n(-c3ccccc3C(F)(F)F)c(=O)c2c1 |(6.94,-44.12,;8.27,-43.35,;9.61,-44.12,;9.61,-45.66,;10.94,-46.43,;12.27,-45.66,;12.27,-44.12,;10.94,-43.35,;10.94,-41.8,;12.02,-40.7,;12.43,-42.19,;9.61,-41.03,;9.61,-39.5,;10.94,-38.73,;10.95,-37.19,;9.61,-36.42,;9.62,-34.88,;8.28,-37.18,;8.28,-38.72,;6.94,-39.49,;13.6,-46.43,;13.6,-47.97,;14.93,-48.74,;16.27,-47.96,;17.6,-48.73,;18.94,-47.96,;20.27,-48.72,;18.93,-46.41,;20.25,-45.63,;21.57,-46.4,;22.89,-45.63,;22.89,-44.09,;21.56,-43.33,;20.23,-44.1,;19.45,-42.76,;17.91,-42.77,;20.21,-41.42,;18.67,-41.43,;17.59,-45.65,;17.58,-44.11,;16.27,-46.42,;14.93,-45.66,)| Show InChI InChI=1S/C27H18F5N5O4S/c1-41-24-23(42(39,40)36-21-9-7-16(28)12-19(21)29)11-15(13-34-24)14-6-8-20-17(10-14)25(38)37(26(33)35-20)22-5-3-2-4-18(22)27(30,31)32/h2-13,36H,1H3,(H2,33,35) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged PI4K-alpha (1 to 2044) (unknown origin) using D-myo-phosphatidylinositol as substrate preincubated for 30 mins followed by s... |
J Med Chem 57: 2091-106 (2014)
Article DOI: 10.1021/jm400781h BindingDB Entry DOI: 10.7270/Q2WH2RG0 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4-kinase alpha (PI4KA)
(Homo sapiens (Human)) | BDBM50448077
(CHEMBL3121308)Show SMILES COc1ncc(cc1S(=O)(=O)Nc1ccc(F)cc1F)-c1ccc2nc(N)n(-c3ccccc3C(F)(F)F)c(=O)c2c1 |(6.94,-44.12,;8.27,-43.35,;9.61,-44.12,;9.61,-45.66,;10.94,-46.43,;12.27,-45.66,;12.27,-44.12,;10.94,-43.35,;10.94,-41.8,;12.02,-40.7,;12.43,-42.19,;9.61,-41.03,;9.61,-39.5,;10.94,-38.73,;10.95,-37.19,;9.61,-36.42,;9.62,-34.88,;8.28,-37.18,;8.28,-38.72,;6.94,-39.49,;13.6,-46.43,;13.6,-47.97,;14.93,-48.74,;16.27,-47.96,;17.6,-48.73,;18.94,-47.96,;20.27,-48.72,;18.93,-46.41,;20.25,-45.63,;21.57,-46.4,;22.89,-45.63,;22.89,-44.09,;21.56,-43.33,;20.23,-44.1,;19.45,-42.76,;17.91,-42.77,;20.21,-41.42,;18.67,-41.43,;17.59,-45.65,;17.58,-44.11,;16.27,-46.42,;14.93,-45.66,)| Show InChI InChI=1S/C27H18F5N5O4S/c1-41-24-23(42(39,40)36-21-9-7-16(28)12-19(21)29)11-15(13-34-24)14-6-8-20-17(10-14)25(38)37(26(33)35-20)22-5-3-2-4-18(22)27(30,31)32/h2-13,36H,1H3,(H2,33,35) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged PI4K-alpha (1 to 2044) (unknown origin) using D-myo-phosphatidylinositol as substrate preincubated for 30 mins followed by s... |
J Med Chem 57: 2091-106 (2014)
Article DOI: 10.1021/jm400781h BindingDB Entry DOI: 10.7270/Q2WH2RG0 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50448077
(CHEMBL3121308)Show SMILES COc1ncc(cc1S(=O)(=O)Nc1ccc(F)cc1F)-c1ccc2nc(N)n(-c3ccccc3C(F)(F)F)c(=O)c2c1 |(6.94,-44.12,;8.27,-43.35,;9.61,-44.12,;9.61,-45.66,;10.94,-46.43,;12.27,-45.66,;12.27,-44.12,;10.94,-43.35,;10.94,-41.8,;12.02,-40.7,;12.43,-42.19,;9.61,-41.03,;9.61,-39.5,;10.94,-38.73,;10.95,-37.19,;9.61,-36.42,;9.62,-34.88,;8.28,-37.18,;8.28,-38.72,;6.94,-39.49,;13.6,-46.43,;13.6,-47.97,;14.93,-48.74,;16.27,-47.96,;17.6,-48.73,;18.94,-47.96,;20.27,-48.72,;18.93,-46.41,;20.25,-45.63,;21.57,-46.4,;22.89,-45.63,;22.89,-44.09,;21.56,-43.33,;20.23,-44.1,;19.45,-42.76,;17.91,-42.77,;20.21,-41.42,;18.67,-41.43,;17.59,-45.65,;17.58,-44.11,;16.27,-46.42,;14.93,-45.66,)| Show InChI InChI=1S/C27H18F5N5O4S/c1-41-24-23(42(39,40)36-21-9-7-16(28)12-19(21)29)11-15(13-34-24)14-6-8-20-17(10-14)25(38)37(26(33)35-20)22-5-3-2-4-18(22)27(30,31)32/h2-13,36H,1H3,(H2,33,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of PI3Kgamma (2 to 1102) (unknown origin) using diC8-PIP2 as substrate preincubated for 30 mins followed by substrate addition measured af... |
J Med Chem 57: 2091-106 (2014)
Article DOI: 10.1021/jm400781h BindingDB Entry DOI: 10.7270/Q2WH2RG0 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50448077
(CHEMBL3121308)Show SMILES COc1ncc(cc1S(=O)(=O)Nc1ccc(F)cc1F)-c1ccc2nc(N)n(-c3ccccc3C(F)(F)F)c(=O)c2c1 |(6.94,-44.12,;8.27,-43.35,;9.61,-44.12,;9.61,-45.66,;10.94,-46.43,;12.27,-45.66,;12.27,-44.12,;10.94,-43.35,;10.94,-41.8,;12.02,-40.7,;12.43,-42.19,;9.61,-41.03,;9.61,-39.5,;10.94,-38.73,;10.95,-37.19,;9.61,-36.42,;9.62,-34.88,;8.28,-37.18,;8.28,-38.72,;6.94,-39.49,;13.6,-46.43,;13.6,-47.97,;14.93,-48.74,;16.27,-47.96,;17.6,-48.73,;18.94,-47.96,;20.27,-48.72,;18.93,-46.41,;20.25,-45.63,;21.57,-46.4,;22.89,-45.63,;22.89,-44.09,;21.56,-43.33,;20.23,-44.1,;19.45,-42.76,;17.91,-42.77,;20.21,-41.42,;18.67,-41.43,;17.59,-45.65,;17.58,-44.11,;16.27,-46.42,;14.93,-45.66,)| Show InChI InChI=1S/C27H18F5N5O4S/c1-41-24-23(42(39,40)36-21-9-7-16(28)12-19(21)29)11-15(13-34-24)14-6-8-20-17(10-14)25(38)37(26(33)35-20)22-5-3-2-4-18(22)27(30,31)32/h2-13,36H,1H3,(H2,33,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of PI3Kgamma (2 to 1102) (unknown origin) using diC8-PIP2 as substrate preincubated for 30 mins followed by substrate addition measured af... |
J Med Chem 57: 2091-106 (2014)
Article DOI: 10.1021/jm400781h BindingDB Entry DOI: 10.7270/Q2WH2RG0 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4-kinase alpha (PI4KA)
(Homo sapiens (Human)) | BDBM50448077
(CHEMBL3121308)Show SMILES COc1ncc(cc1S(=O)(=O)Nc1ccc(F)cc1F)-c1ccc2nc(N)n(-c3ccccc3C(F)(F)F)c(=O)c2c1 |(6.94,-44.12,;8.27,-43.35,;9.61,-44.12,;9.61,-45.66,;10.94,-46.43,;12.27,-45.66,;12.27,-44.12,;10.94,-43.35,;10.94,-41.8,;12.02,-40.7,;12.43,-42.19,;9.61,-41.03,;9.61,-39.5,;10.94,-38.73,;10.95,-37.19,;9.61,-36.42,;9.62,-34.88,;8.28,-37.18,;8.28,-38.72,;6.94,-39.49,;13.6,-46.43,;13.6,-47.97,;14.93,-48.74,;16.27,-47.96,;17.6,-48.73,;18.94,-47.96,;20.27,-48.72,;18.93,-46.41,;20.25,-45.63,;21.57,-46.4,;22.89,-45.63,;22.89,-44.09,;21.56,-43.33,;20.23,-44.1,;19.45,-42.76,;17.91,-42.77,;20.21,-41.42,;18.67,-41.43,;17.59,-45.65,;17.58,-44.11,;16.27,-46.42,;14.93,-45.66,)| Show InChI InChI=1S/C27H18F5N5O4S/c1-41-24-23(42(39,40)36-21-9-7-16(28)12-19(21)29)11-15(13-34-24)14-6-8-20-17(10-14)25(38)37(26(33)35-20)22-5-3-2-4-18(22)27(30,31)32/h2-13,36H,1H3,(H2,33,35) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged PI4K-alpha (1 to 2044) (unknown origin) using D-myo-phosphatidylinositol as substrate preincubated for 30 mins followed by s... |
J Med Chem 57: 2091-106 (2014)
Article DOI: 10.1021/jm400781h BindingDB Entry DOI: 10.7270/Q2WH2RG0 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50448077
(CHEMBL3121308)Show SMILES COc1ncc(cc1S(=O)(=O)Nc1ccc(F)cc1F)-c1ccc2nc(N)n(-c3ccccc3C(F)(F)F)c(=O)c2c1 |(6.94,-44.12,;8.27,-43.35,;9.61,-44.12,;9.61,-45.66,;10.94,-46.43,;12.27,-45.66,;12.27,-44.12,;10.94,-43.35,;10.94,-41.8,;12.02,-40.7,;12.43,-42.19,;9.61,-41.03,;9.61,-39.5,;10.94,-38.73,;10.95,-37.19,;9.61,-36.42,;9.62,-34.88,;8.28,-37.18,;8.28,-38.72,;6.94,-39.49,;13.6,-46.43,;13.6,-47.97,;14.93,-48.74,;16.27,-47.96,;17.6,-48.73,;18.94,-47.96,;20.27,-48.72,;18.93,-46.41,;20.25,-45.63,;21.57,-46.4,;22.89,-45.63,;22.89,-44.09,;21.56,-43.33,;20.23,-44.1,;19.45,-42.76,;17.91,-42.77,;20.21,-41.42,;18.67,-41.43,;17.59,-45.65,;17.58,-44.11,;16.27,-46.42,;14.93,-45.66,)| Show InChI InChI=1S/C27H18F5N5O4S/c1-41-24-23(42(39,40)36-21-9-7-16(28)12-19(21)29)11-15(13-34-24)14-6-8-20-17(10-14)25(38)37(26(33)35-20)22-5-3-2-4-18(22)27(30,31)32/h2-13,36H,1H3,(H2,33,35) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.51E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of PI3Kgamma (2 to 1102) (unknown origin) using diC8-PIP2 as substrate preincubated for 30 mins followed by substrate addition measured af... |
J Med Chem 57: 2091-106 (2014)
Article DOI: 10.1021/jm400781h BindingDB Entry DOI: 10.7270/Q2WH2RG0 |
More data for this Ligand-Target Pair | |