BDBM50448101 CHEMBL3121329

SMILES: COc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1ccc2nc(N)c(cc2c1)-c1ccccc1

InChI Key: InChIKey=ISKUKBKBISOCEK-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50448101   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM50448101 (CHEMBL3121329) Show SMILES COc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1ccc2nc(N)c(cc2c1)-c1ccccc1 Show InChI InChI=1S/C27H20F2N4O3S/c1-36-27-24(33-37(34,35)25-10-8-20(28)14-22(25)29)13-19(15-31-27)17-7-9-23-18(11-17)12-21(26(30)32-23)16-5-3-2-4-6-16/h2-15,33H,1H3,(H2,30,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of PI3Kgamma (2 to 1102) (unknown origin) using diC8-PIP2 as substrate preincubated for 30 mins followed by substrate addition measured af...				J Med Chem 57: 2091-106 (2014) Article DOI: 10.1021/jm400781h BindingDB Entry DOI: 10.7270/Q2WH2RG0
					More data for this Ligand-Target Pair
Phosphatidylinositol 4-kinase alpha (PI4KA) (Homo sapiens (Human))	BDBM50448101 (CHEMBL3121329) Show SMILES COc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1ccc2nc(N)c(cc2c1)-c1ccccc1 Show InChI InChI=1S/C27H20F2N4O3S/c1-36-27-24(33-37(34,35)25-10-8-20(28)14-22(25)29)13-19(15-31-27)17-7-9-23-18(11-17)12-21(26(30)32-23)16-5-3-2-4-6-16/h2-15,33H,1H3,(H2,30,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of GST-tagged PI4K-alpha (1 to 2044) (unknown origin) using D-myo-phosphatidylinositol as substrate preincubated for 30 mins followed by s...				J Med Chem 57: 2091-106 (2014) Article DOI: 10.1021/jm400781h BindingDB Entry DOI: 10.7270/Q2WH2RG0
					More data for this Ligand-Target Pair