BDBM50448144 CHEMBL3122212
SMILES: Cc1ccncc1-c1nn(C)c2nc(OCc3ccccn3)cnc12
InChI Key: InChIKey=RDLSKDOSNKLEAQ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50448144 (CHEMBL3122212) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Displacement of [3H]-MPEPy from human mGluR5 expressed in HEK293FT cells after 1 hr by liquid scintillation counting analysis | J Med Chem 57: 861-77 (2014) Article DOI: 10.1021/jm401622k BindingDB Entry DOI: 10.7270/Q27P90WR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (Homo sapiens (Human)) | BDBM50448144 (CHEMBL3122212) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Negative allosteric modulation of human mGluR1 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium flux after 16 to 24 hrs ... | J Med Chem 57: 861-77 (2014) Article DOI: 10.1021/jm401622k BindingDB Entry DOI: 10.7270/Q27P90WR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (Homo sapiens (Human)) | BDBM50448144 (CHEMBL3122212) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of PDE11 (unknown origin) | J Med Chem 57: 861-77 (2014) Article DOI: 10.1021/jm401622k BindingDB Entry DOI: 10.7270/Q27P90WR | |||||||||||
More data for this Ligand-Target Pair |