Found 3 hits for monomerid = 50448734 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50448734
(CHEMBL3127865)Show SMILES COC[C@H](C)Oc1nc(C2CC2)c(s1)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 |r,wU:24.27,3.3,wD:17.18,TLB:16:17:21:23.24.26,27:24:17.18.19:21,THB:27:18:21:23.24.26,26:24:17:19.20.21,26:20:17:23.27.24,25:24:17:19.20.21,25:24:17.18.19:21,(1.68,-19.21,;3.13,-19.71,;4.29,-18.7,;5.75,-19.2,;6.05,-20.71,;6.91,-18.18,;8.37,-18.68,;8.82,-20.16,;10.36,-20.18,;11.25,-21.43,;11.39,-22.97,;12.65,-22.08,;10.86,-18.72,;9.63,-17.8,;12.19,-17.95,;12.18,-16.41,;13.53,-18.71,;14.86,-17.94,;16.36,-17.55,;16.38,-15.96,;17.44,-14.74,;16.09,-15.2,;16.07,-16.69,;17.39,-17.2,;18.8,-16.88,;20.34,-16.84,;18.84,-15.35,;17.76,-18.14,)| Show InChI InChI=1S/C21H30N2O4S/c1-11(10-26-2)27-20-23-17(13-3-4-13)18(28-20)19(24)22-16-14-5-12-6-15(16)9-21(25,7-12)8-14/h11-16,25H,3-10H2,1-2H3,(H,22,24)/t11-,12?,14?,15?,16-,21-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of recombinant human 11beta-HSD1 using cortisone/[3H]-cortisone as substrate after 5 hrs by reverse-phase HPLC analysis |
J Med Chem 57: 970-86 (2014)
Article DOI: 10.1021/jm4016729 BindingDB Entry DOI: 10.7270/Q2Z32149 |
More data for this Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Mus musculus (mouse)) | BDBM50448734
(CHEMBL3127865)Show SMILES COC[C@H](C)Oc1nc(C2CC2)c(s1)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 |r,wU:24.27,3.3,wD:17.18,TLB:16:17:21:23.24.26,27:24:17.18.19:21,THB:27:18:21:23.24.26,26:24:17:19.20.21,26:20:17:23.27.24,25:24:17:19.20.21,25:24:17.18.19:21,(1.68,-19.21,;3.13,-19.71,;4.29,-18.7,;5.75,-19.2,;6.05,-20.71,;6.91,-18.18,;8.37,-18.68,;8.82,-20.16,;10.36,-20.18,;11.25,-21.43,;11.39,-22.97,;12.65,-22.08,;10.86,-18.72,;9.63,-17.8,;12.19,-17.95,;12.18,-16.41,;13.53,-18.71,;14.86,-17.94,;16.36,-17.55,;16.38,-15.96,;17.44,-14.74,;16.09,-15.2,;16.07,-16.69,;17.39,-17.2,;18.8,-16.88,;20.34,-16.84,;18.84,-15.35,;17.76,-18.14,)| Show InChI InChI=1S/C21H30N2O4S/c1-11(10-26-2)27-20-23-17(13-3-4-13)18(28-20)19(24)22-16-14-5-12-6-15(16)9-21(25,7-12)8-14/h11-16,25H,3-10H2,1-2H3,(H,22,24)/t11-,12?,14?,15?,16-,21-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.80 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of N-terminal 6-His-tagged full-length mouse 11beta-HSD1 assessed as conversion of cortisone to cortisol after 25 mins by competitive HTRF... |
J Med Chem 57: 970-86 (2014)
Article DOI: 10.1021/jm4016729 BindingDB Entry DOI: 10.7270/Q2Z32149 |
More data for this Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50448734
(CHEMBL3127865)Show SMILES COC[C@H](C)Oc1nc(C2CC2)c(s1)C(=O)N[C@H]1C2CC3CC1C[C@](O)(C3)C2 |r,wU:24.27,3.3,wD:17.18,TLB:16:17:21:23.24.26,27:24:17.18.19:21,THB:27:18:21:23.24.26,26:24:17:19.20.21,26:20:17:23.27.24,25:24:17:19.20.21,25:24:17.18.19:21,(1.68,-19.21,;3.13,-19.71,;4.29,-18.7,;5.75,-19.2,;6.05,-20.71,;6.91,-18.18,;8.37,-18.68,;8.82,-20.16,;10.36,-20.18,;11.25,-21.43,;11.39,-22.97,;12.65,-22.08,;10.86,-18.72,;9.63,-17.8,;12.19,-17.95,;12.18,-16.41,;13.53,-18.71,;14.86,-17.94,;16.36,-17.55,;16.38,-15.96,;17.44,-14.74,;16.09,-15.2,;16.07,-16.69,;17.39,-17.2,;18.8,-16.88,;20.34,-16.84,;18.84,-15.35,;17.76,-18.14,)| Show InChI InChI=1S/C21H30N2O4S/c1-11(10-26-2)27-20-23-17(13-3-4-13)18(28-20)19(24)22-16-14-5-12-6-15(16)9-21(25,7-12)8-14/h11-16,25H,3-10H2,1-2H3,(H,22,24)/t11-,12?,14?,15?,16-,21-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of N-terminal 6-His-tagged full-length human 11beta-HSD1 assessed as conversion of cortisone to cortisol after 25 mins by competitive HTRF... |
J Med Chem 57: 970-86 (2014)
Article DOI: 10.1021/jm4016729 BindingDB Entry DOI: 10.7270/Q2Z32149 |
More data for this Ligand-Target Pair | |