null

SMILES: Cc1nc2ccc(cc2n1-c1ncnc(N)n1)C#CC(C)(C)CO

InChI Key: InChIKey=NHHKXIKJWPOLLY-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50448784   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase PAK 4 (Homo sapiens (Human))	BDBM50448784 (CHEMBL3128045) Show SMILES Cc1nc2ccc(cc2n1-c1ncnc(N)n1)C#CC(C)(C)CO Show InChI InChI=1S/C17H18N6O/c1-11-21-13-5-4-12(6-7-17(2,3)9-24)8-14(13)23(11)16-20-10-19-15(18)22-16/h4-5,8,10,24H,9H2,1-3H3,(H2,18,19,20,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Binding affinity to N-terminal GST-tagged recombinant human PAK4 kinase domain expressed in Escherichia coli using KKRNRRLSVA as substrate preincubat...				J Med Chem 57: 1033-45 (2014) Article DOI: 10.1021/jm401768t BindingDB Entry DOI: 10.7270/Q2F47QNW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PAK 1 (Homo sapiens (Human))	BDBM50448784 (CHEMBL3128045) Show SMILES Cc1nc2ccc(cc2n1-c1ncnc(N)n1)C#CC(C)(C)CO Show InChI InChI=1S/C17H18N6O/c1-11-21-13-5-4-12(6-7-17(2,3)9-24)8-14(13)23(11)16-20-10-19-15(18)22-16/h4-5,8,10,24H,9H2,1-3H3,(H2,18,19,20,22)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>4.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Binding affinity to N-terminal GST-His-tagged recombinant human PAK1 kinase domain expressed in Escherichia coli BL21 using KKRNRRLSVA as sustrate pr...				J Med Chem 57: 1033-45 (2014) Article DOI: 10.1021/jm401768t BindingDB Entry DOI: 10.7270/Q2F47QNW
					More data for this Ligand-Target Pair