BDBM50448810 CHEMBL3128230
SMILES: Fc1ccc(cc1)C(=O)Nc1cccc(CNc2ncnc3n(CCc4ccccc4)ncc23)c1
InChI Key: InChIKey=ZNVLZAOELIFLMB-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50448810 (CHEMBL3128230) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.64E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa Curated by ChEMBL | Assay Description Inhibition of recombinant human RET incubated for 5 mins with substrate prior to protein addition by fluorescence assay | J Med Chem 57: 1225-35 (2014) Article DOI: 10.1021/jm401358b BindingDB Entry DOI: 10.7270/Q2X34ZZP | |||||||||||
More data for this Ligand-Target Pair |