BDBM50448813 CHEMBL3128226

SMILES: O=S(=O)(Cc1ccccc1)Nc1cccc(CNc2ncnc3n(CCc4ccccc4)ncc23)c1

InChI Key: InChIKey=FAASTMSXLOAGEV-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50448813   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50448813 (CHEMBL3128226) Show SMILES O=S(=O)(Cc1ccccc1)Nc1cccc(CNc2ncnc3n(CCc4ccccc4)ncc23)c1 Show InChI InChI=1S/C27H26N6O2S/c34-36(35,19-22-10-5-2-6-11-22)32-24-13-7-12-23(16-24)17-28-26-25-18-31-33(27(25)30-20-29-26)15-14-21-8-3-1-4-9-21/h1-13,16,18,20,32H,14-15,17,19H2,(H,28,29,30)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.86E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Pisa Curated by ChEMBL					Assay Description Inhibition of recombinant human RET incubated for 5 mins with substrate prior to protein addition by fluorescence assay				J Med Chem 57: 1225-35 (2014) Article DOI: 10.1021/jm401358b BindingDB Entry DOI: 10.7270/Q2X34ZZP
					More data for this Ligand-Target Pair