BDBM50448970 CHEMBL3125518::US9296736, 295::US9593129, Example 295

SMILES: CC(C)[C@@H](CN(C)S(=O)(=O)C1CC1)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1

InChI Key: InChIKey=NAOFRLUOVJQSJF-GCMXZSHTSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50448970   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MDM2 and p53 (Homo sapiens (Human))	BDBM50448970 (CHEMBL3125518 | US9296736, 295 | US9593129, Exampl...) Show SMILES CC(C)[C@@H](CN(C)S(=O)(=O)C1CC1)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C29H36Cl2N2O5S/c1-18(2)25(17-32(4)39(37,38)23-12-13-23)33-27(19-8-10-21(30)11-9-19)24(20-6-5-7-22(31)14-20)15-29(3,28(33)36)16-26(34)35/h5-11,14,18,23-25,27H,12-13,15-17H2,1-4H3,(H,34,35)/t24-,25-,27-,29-/m1/s1	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	7.4	25
Amgen INC. US Patent					Assay Description The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...				US Patent US9296736 (2016) BindingDB Entry DOI: 10.7270/Q29022M2
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (aa 1-188) (Homo sapiens (Human))	BDBM50448970 (CHEMBL3125518 | US9296736, 295 | US9593129, Exampl...) Show SMILES CC(C)[C@@H](CN(C)S(=O)(=O)C1CC1)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C29H36Cl2N2O5S/c1-18(2)25(17-32(4)39(37,38)23-12-13-23)33-27(19-8-10-21(30)11-9-19)24(20-6-5-7-22(31)14-20)15-29(3,28(33)36)16-26(34)35/h5-11,14,18,23-25,27H,12-13,15-17H2,1-4H3,(H,34,35)/t24-,25-,27-,29-/m1/s1	PDB GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. US Patent					Assay Description The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...				US Patent US9593129 (2017) BindingDB Entry DOI: 10.7270/Q20P1232
					More data for this Ligand-Target Pair
MDM2-MDMX (Homo sapiens (Human))	BDBM50448970 (CHEMBL3125518 | US9296736, 295 | US9593129, Exampl...) Show SMILES CC(C)[C@@H](CN(C)S(=O)(=O)C1CC1)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C29H36Cl2N2O5S/c1-18(2)25(17-32(4)39(37,38)23-12-13-23)33-27(19-8-10-21(30)11-9-19)24(20-6-5-7-22(31)14-20)15-29(3,28(33)36)16-26(34)35/h5-11,14,18,23-25,27H,12-13,15-17H2,1-4H3,(H,34,35)/t24-,25-,27-,29-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Binding affinity to human GST-thrombin-tagged MDM2 assessed as inhibition of interaction with human p53 after 1 hr by HTRF assay				J Med Chem 57: 1454-72 (2014) Article DOI: 10.1021/jm401753e BindingDB Entry DOI: 10.7270/Q24M960Z
					More data for this Ligand-Target Pair