null

SMILES: CN1C(=O)\C(=C/c2[nH]c(C)cc2C)c2c1ncnc2Nc1ccc(F)c(Cl)c1

InChI Key: InChIKey=WAYQKXZMUDFDDG-JYRVWZFOSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 5131   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5131 ((5Z)-4-[(3-chloro-4-fluorophenyl)amino]-5-[(3,5-di...) Show SMILES CN1C(=O)\C(=C/c2[nH]c(C)cc2C)c2c1ncnc2Nc1ccc(F)c(Cl)c1 Show InChI InChI=1S/C20H17ClFN5O/c1-10-6-11(2)25-16(10)8-13-17-18(23-9-24-19(17)27(3)20(13)28)26-12-4-5-15(22)14(21)7-12/h4-9,25H,1-3H3,(H,23,24,26)/b13-8-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.82E+3	n/a	n/a	n/a	n/a	7.5	22
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM5131 ((5Z)-4-[(3-chloro-4-fluorophenyl)amino]-5-[(3,5-di...) Show SMILES CN1C(=O)\C(=C/c2[nH]c(C)cc2C)c2c1ncnc2Nc1ccc(F)c(Cl)c1 Show InChI InChI=1S/C20H17ClFN5O/c1-10-6-11(2)25-16(10)8-13-17-18(23-9-24-19(17)27(3)20(13)28)26-12-4-5-15(22)14(21)7-12/h4-9,25H,1-3H3,(H,23,24,26)/b13-8-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM5131 ((5Z)-4-[(3-chloro-4-fluorophenyl)amino]-5-[(3,5-di...) Show SMILES CN1C(=O)\C(=C/c2[nH]c(C)cc2C)c2c1ncnc2Nc1ccc(F)c(Cl)c1 Show InChI InChI=1S/C20H17ClFN5O/c1-10-6-11(2)25-16(10)8-13-17-18(23-9-24-19(17)27(3)20(13)28)26-12-4-5-15(22)14(21)7-12/h4-9,25H,1-3H3,(H,23,24,26)/b13-8-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair