BDBM5136 (5Z)-4-[(3-chloro-4-fluorophenyl)amino]-5-({3-methyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl}methylidene)-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-6-one::pyrrolo[2,3-d]pyrimidin-6-one deriv. 26n

SMILES: CN1CCN(CC1)C(=O)c1c[nH]c(\C=C2/C(=O)Nc3ncnc(Nc4ccc(F)c(Cl)c4)c23)c1C

InChI Key: InChIKey=UYSSUZUSGKWSFS-GDNBJRDFSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 5136   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5136 ((5Z)-4-[(3-chloro-4-fluorophenyl)amino]-5-({3-meth...) Show SMILES CN1CCN(CC1)C(=O)c1c[nH]c(\C=C2/C(=O)Nc3ncnc(Nc4ccc(F)c(Cl)c4)c23)c1C Show InChI InChI=1S/C24H23ClFN7O2/c1-13-16(24(35)33-7-5-32(2)6-8-33)11-27-19(13)10-15-20-21(28-12-29-22(20)31-23(15)34)30-14-3-4-18(26)17(25)9-14/h3-4,9-12,27H,5-8H2,1-2H3,(H2,28,29,30,31,34)/b15-10-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	7.5	22
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM5136 ((5Z)-4-[(3-chloro-4-fluorophenyl)amino]-5-({3-meth...) Show SMILES CN1CCN(CC1)C(=O)c1c[nH]c(\C=C2/C(=O)Nc3ncnc(Nc4ccc(F)c(Cl)c4)c23)c1C Show InChI InChI=1S/C24H23ClFN7O2/c1-13-16(24(35)33-7-5-32(2)6-8-33)11-27-19(13)10-15-20-21(28-12-29-22(20)31-23(15)34)30-14-3-4-18(26)17(25)9-14/h3-4,9-12,27H,5-8H2,1-2H3,(H2,28,29,30,31,34)/b15-10-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM5136 ((5Z)-4-[(3-chloro-4-fluorophenyl)amino]-5-({3-meth...) Show SMILES CN1CCN(CC1)C(=O)c1c[nH]c(\C=C2/C(=O)Nc3ncnc(Nc4ccc(F)c(Cl)c4)c23)c1C Show InChI InChI=1S/C24H23ClFN7O2/c1-13-16(24(35)33-7-5-32(2)6-8-33)11-27-19(13)10-15-20-21(28-12-29-22(20)31-23(15)34)30-14-3-4-18(26)17(25)9-14/h3-4,9-12,27H,5-8H2,1-2H3,(H2,28,29,30,31,34)/b15-10-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair