BDBM5171 (2E)-2-[(3,4-dihydroxyphenyl)carbonyl]-3-(1H-indol-3-yl)prop-2-enenitrile::Indole-Containing Inhibitor 5

SMILES: Oc1ccc(cc1O)C(=O)C(=C\c1c[nH]c2ccccc12)\C#N

InChI Key: InChIKey=TTZDOBVWBQXGDC-KPKJPENVSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 5171   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM5171 ((2E)-2-[(3,4-dihydroxyphenyl)carbonyl]-3-(1H-indol...) Show SMILES Oc1ccc(cc1O)C(=O)C(=C\c1c[nH]c2ccccc12)\C#N Show InChI InChI=1S/C18H12N2O3/c19-9-12(18(23)11-5-6-16(21)17(22)8-11)7-13-10-20-15-4-2-1-3-14(13)15/h1-8,10,20-22H/b12-7+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	7.5	4
Hebrew University of Jerusalem					Assay Description The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...				J Med Chem 39: 2170-7 (1996) Article DOI: 10.1021/jm950727b BindingDB Entry DOI: 10.7270/Q2QF8R2N
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BRK (Homo sapiens (Human))	BDBM5171 ((2E)-2-[(3,4-dihydroxyphenyl)carbonyl]-3-(1H-indol...) Show SMILES Oc1ccc(cc1O)C(=O)C(=C\c1c[nH]c2ccccc12)\C#N Show InChI InChI=1S/C18H12N2O3/c19-9-12(18(23)11-5-6-16(21)17(22)8-11)7-13-10-20-15-4-2-1-3-14(13)15/h1-8,10,20-22H/b12-7+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.32E+4	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Inhibition of PTK6 (unknown origin) expressed in HEK293 cells assessed as decrease in tyrosine phosphorylation by chemiluminescence assay				Bioorg Med Chem Lett 24: 4659-63 (2014) Article DOI: 10.1016/j.bmcl.2014.08.036 BindingDB Entry DOI: 10.7270/Q2TH8P84
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BRK (Homo sapiens (Human))	BDBM5171 ((2E)-2-[(3,4-dihydroxyphenyl)carbonyl]-3-(1H-indol...) Show SMILES Oc1ccc(cc1O)C(=O)C(=C\c1c[nH]c2ccccc12)\C#N Show InChI InChI=1S/C18H12N2O3/c19-9-12(18(23)11-5-6-16(21)17(22)8-11)7-13-10-20-15-4-2-1-3-14(13)15/h1-8,10,20-22H/b12-7+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.32E+3	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Inhibition of GST-tagged PTK6 (unknown origin) assessed as phosphorylated tyrosines after 20 mins by ELISA				Bioorg Med Chem Lett 24: 4659-63 (2014) Article DOI: 10.1016/j.bmcl.2014.08.036 BindingDB Entry DOI: 10.7270/Q2TH8P84
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM5171 ((2E)-2-[(3,4-dihydroxyphenyl)carbonyl]-3-(1H-indol...) Show SMILES Oc1ccc(cc1O)C(=O)C(=C\c1c[nH]c2ccccc12)\C#N Show InChI InChI=1S/C18H12N2O3/c19-9-12(18(23)11-5-6-16(21)17(22)8-11)7-13-10-20-15-4-2-1-3-14(13)15/h1-8,10,20-22H/b12-7+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Hebrew University of Jerusalem					Assay Description The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...				J Med Chem 39: 2170-7 (1996) Article DOI: 10.1021/jm950727b BindingDB Entry DOI: 10.7270/Q2QF8R2N
					More data for this Ligand-Target Pair