BDBM5177 3-amino-5-[(1Z)-1-cyano-2-(1H-indol-3-yl)eth-1-en-1-yl]-1H-pyrazole-4-carbonitrile::Indole-Containing Inhibitor 11
SMILES: Nc1[nH]nc(C(=Cc2c[nH]c3ccccc23)C#N)c1C#N
InChI Key: InChIKey=OJMXHLJIMZMFGX-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Platelet-derived growth factor receptor beta (Homo sapiens (Human)) | BDBM5177 (3-amino-5-[(1Z)-1-cyano-2-(1H-indol-3-yl)eth-1-en-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Hebrew University of Jerusalem | Assay Description The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ... | J Med Chem 39: 2170-7 (1996) Article DOI: 10.1021/jm950727b BindingDB Entry DOI: 10.7270/Q2QF8R2N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM5177 (3-amino-5-[(1Z)-1-cyano-2-(1H-indol-3-yl)eth-1-en-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Hebrew University of Jerusalem | Assay Description The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ... | J Med Chem 39: 2170-7 (1996) Article DOI: 10.1021/jm950727b BindingDB Entry DOI: 10.7270/Q2QF8R2N | |||||||||||
More data for this Ligand-Target Pair |