BindingDB PrimarySearch

BDBM5185 (2-(p-Nitrophenyl)-3-carbomethoxy-6,7-dimethoxyquinoline)::Quinoline-Containing Inhibitor 19::methyl 6,7-dimethoxy-2-(4-nitrophenyl)quinoline-3-carboxylate

SMILES: COC(=O)c1cc2cc(OC)c(OC)cc2nc1-c1ccc(cc1)[N+]([O-])=O

InChI Key: InChIKey=ZHROVCLRKOLMGN-UHFFFAOYSA-N

Data: 2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 5185
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM5185 ((2-(p-Nitrophenyl)-3-carbomethoxy-6,7-dimethoxyqui...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Hebrew University of Jerusalem					Assay Description The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...				J Med Chem 39: 2170-7 (1996) Article DOI: 10.1021/jm950727b BindingDB Entry DOI: 10.7270/Q2QF8R2N
Hebrew University of Jerusalem					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM5185 ((2-(p-Nitrophenyl)-3-carbomethoxy-6,7-dimethoxyqui...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	7.5	4
Hebrew University of Jerusalem					Assay Description The assay was using Swiss 3T3 cell membranes harboring EGF-R or PDGFR-beta. Receptor autophosphorylation was initiated by addition of [gamma-32P]ATP ...				J Med Chem 39: 2170-7 (1996) Article DOI: 10.1021/jm950727b BindingDB Entry DOI: 10.7270/Q2QF8R2N
Hebrew University of Jerusalem					More data for this Ligand-Target Pair