BDBM5292 2-({4-[(4-methanesulfonylpiperidin-1-yl)methyl]pyridin-2-yl}amino)-1,3-thiazole-5-carbonitrile::2-[(4-{[4-(Methylsulfonyl)piperidin-1-yl]methyl}pyridin-2-yl)amino]-1,3-thiazole-5-carbonitrile::N-(1,3-Thiazol-2-yl)pyridin-2-amine 22

SMILES: CS(=O)(=O)C1CCN(Cc2ccnc(Nc3ncc(s3)C#N)c2)CC1

InChI Key: InChIKey=MAUCYALFIUOTRM-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 5292   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5292 (2-({4-[(4-methanesulfonylpiperidin-1-yl)methyl]pyr...) Show SMILES CS(=O)(=O)C1CCN(Cc2ccnc(Nc3ncc(s3)C#N)c2)CC1 Show InChI InChI=1S/C16H19N5O2S2/c1-25(22,23)14-3-6-21(7-4-14)11-12-2-5-18-15(8-12)20-16-19-10-13(9-17)24-16/h2,5,8,10,14H,3-4,6-7,11H2,1H3,(H,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				J Med Chem 47: 6363-72 (2004) Article DOI: 10.1021/jm049697f BindingDB Entry DOI: 10.7270/Q2PG1PXD
					More data for this Ligand-Target Pair