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SMILES: O=C(N1CCNCC1)c1ccc2[nH]c(cc2c1)-c1cc2ccccc2[nH]c1=O

InChI Key: InChIKey=BFXROLSTCOFFGC-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 5334   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM5334
PNG
(3-[5-(piperazin-1-ylcarbonyl)-1H-indol-2-yl]-1,2-d...)
Show SMILES O=C(N1CCNCC1)c1ccc2[nH]c(cc2c1)-c1cc2ccccc2[nH]c1=O
Show InChI InChI=1S/C22H20N4O2/c27-21-17(12-14-3-1-2-4-18(14)25-21)20-13-16-11-15(5-6-19(16)24-20)22(28)26-9-7-23-8-10-26/h1-6,11-13,23-24H,7-10H2,(H,25,27)
PDB
MMDB

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Article
PubMed
n/an/a 5n/an/an/an/a7.422



Merck Research Laboratories



Assay Description
Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...

Bioorg Med Chem Lett 14: 351-5 (2004)


Article DOI: 10.1016/j.bmcl.2003.11.007
BindingDB Entry DOI: 10.7270/Q298856Z
More data for this
Ligand-Target Pair