BDBM5430 4-[3-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-6-yl]pyridine::pyrazolo[1,5-a]pyrimidine 3e

SMILES: COc1ccc(cc1)-c1cnn2cc(cnc12)-c1ccncc1

InChI Key: InChIKey=ZPOVCQHUDFHVQK-UHFFFAOYSA-N

Data: 1 IC50  1 Other

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 5430   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5430 (4-[3-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-6-y...) Show SMILES COc1ccc(cc1)-c1cnn2cc(cnc12)-c1ccncc1 Show InChI InChI=1S/C18H14N4O/c1-23-16-4-2-14(3-5-16)17-11-21-22-12-15(10-20-18(17)22)13-6-8-19-9-7-13/h2-12H,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
University of KwaZulu-Natal Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-fused KDR kinase expressed in insect Sf21 cells using poly-Glu/Tyr (4:1) peptide as substrate				Eur J Med Chem 126: 298-352 (2017) BindingDB Entry DOI: 10.7270/Q2S184RN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5430 (4-[3-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-6-y...) Show SMILES COc1ccc(cc1)-c1cnn2cc(cnc12)-c1ccncc1 Show InChI InChI=1S/C18H14N4O/c1-23-16-4-2-14(3-5-16)17-11-21-22-12-15(10-20-18(17)22)13-6-8-19-9-7-13/h2-12H,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 12: 2767-70 (2002) Article DOI: 10.1016/s0960-894x(02)00525-5 BindingDB Entry DOI: 10.7270/Q2NG4NTG
					More data for this Ligand-Target Pair