BDBM5432 6-(4-methoxyphenyl)-3-(thiophen-3-yl)pyrazolo[1,5-a]pyrimidine::CHEMBL92461::pyrazolo[1,5-a]pyrimidine 3g

SMILES: COc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccsc1

InChI Key: InChIKey=HBWLNACPIFKNIP-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 5432   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5432 (6-(4-methoxyphenyl)-3-(thiophen-3-yl)pyrazolo[1,5-...) Show SMILES COc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccsc1 Show InChI InChI=1S/C17H13N3OS/c1-21-15-4-2-12(3-5-15)14-8-18-17-16(9-19-20(17)10-14)13-6-7-22-11-13/h2-11H,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	7.4	22
Merck Research Laboratories					Assay Description Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...				Bioorg Med Chem Lett 12: 2767-70 (2002) Article DOI: 10.1016/s0960-894x(02)00525-5 BindingDB Entry DOI: 10.7270/Q2NG4NTG
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5432 (6-(4-methoxyphenyl)-3-(thiophen-3-yl)pyrazolo[1,5-...) Show SMILES COc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccsc1 Show InChI InChI=1S/C17H13N3OS/c1-21-15-4-2-12(3-5-15)14-8-18-17-16(9-19-20(17)10-14)13-6-7-22-11-13/h2-11H,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Chaminade University of Honolulu Curated by ChEMBL					Assay Description Inhibition of human recombinant His-tagged VEGFR2 assessed as infrared absorption by ELISA assay in presence of 20 uM ATP				Bioorg Med Chem Lett 21: 1371-5 (2011) Checked by Author Article DOI: 10.1016/j.bmcl.2011.01.037 BindingDB Entry DOI: 10.7270/Q21J9B1F
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5432 (6-(4-methoxyphenyl)-3-(thiophen-3-yl)pyrazolo[1,5-...) Show SMILES COc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccsc1 Show InChI InChI=1S/C17H13N3OS/c1-21-15-4-2-12(3-5-15)14-8-18-17-16(9-19-20(17)10-14)13-6-7-22-11-13/h2-11H,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	185	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR (unknown origin) by HTRF assay				J Med Chem 51: 3777-87 (2008) Article DOI: 10.1021/jm701397k BindingDB Entry DOI: 10.7270/Q22R3RFW
					More data for this Ligand-Target Pair