BDBM55084 N-[4-[(2-chlorobenzoyl)amino]-3-fluoro-phenyl]picolinamide::N-[4-[(2-chlorobenzoyl)amino]-3-fluorophenyl]pyridine-2-carboxamide::N-[4-[(2-chlorophenyl)carbonylamino]-3-fluoranyl-phenyl]pyridine-2-carboxamide::N-[4-[[(2-chlorophenyl)-oxomethyl]amino]-3-fluorophenyl]-2-pyridinecarboxamide::VU0362060-1::cid_46869942
SMILES: Fc1cc(NC(=O)c2ccccn2)ccc1NC(=O)c1ccccc1Cl
InChI Key: InChIKey=NYDUFWZZLKDRLO-UHFFFAOYSA-N
Data: 4 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Metabotropic glutamate receptor 4 (Homo sapiens (Human)) | BDBM55084 (N-[4-[(2-chlorobenzoyl)amino]-3-fluoro-phenyl]pico...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | n/a | n/a | 480 | n/a | n/a | n/a | n/a |
Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Curated by PubChem BioAssay | Assay Description Assay Provider: Colleen Niswender Assay Provider Affiliation: Vanderbilt University The primary pathophysiological change giving rise to the symptoms... | PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2VT1QHF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM55084 (N-[4-[(2-chlorobenzoyl)amino]-3-fluoro-phenyl]pico...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 739 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Positive allosteric modulation of rat mGluR4 expressed in CHO cells coexpressing Gqi5 assessed as calcium mobilization | J Med Chem 54: 1106-10 (2011) Article DOI: 10.1021/jm101271s BindingDB Entry DOI: 10.7270/Q27P90C1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 4 (Homo sapiens (Human)) | BDBM55084 (N-[4-[(2-chlorobenzoyl)amino]-3-fluoro-phenyl]pico...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 556 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Positive allosteric modulation of human mGluR4 expressed in CHO cells coexpressing Gqi5 assessed as calcium mobilization | J Med Chem 54: 1106-10 (2011) Article DOI: 10.1021/jm101271s BindingDB Entry DOI: 10.7270/Q27P90C1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 4 [Q124R] (Rattus norvegicus) | BDBM55084 (N-[4-[(2-chlorobenzoyl)amino]-3-fluoro-phenyl]pico...) | PDB KEGG GoogleScholar AffyNet | PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | n/a | n/a | 740 | n/a | n/a | n/a | n/a |
Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters Curated by PubChem BioAssay | Assay Description Assay Provider: Colleen Niswender Assay Provider Affiliation: Vanderbilt University The primary pathophysiological change giving rise to the symptoms... | PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2DR2SWV | |||||||||||
More data for this Ligand-Target Pair |