Found 6 hits for monomerid = 5775 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cyclin-Dependent Kinase 1 (CDK1)
(Homo sapiens (Human)) | BDBM5775
(4-butoxy-5-[(2,4,6-trifluorophenyl)carbonyl]-1H-py...)Show SMILES CCCCOc1c(cnc2[nH]ncc12)C(=O)c1c(F)cc(F)cc1F Show InChI InChI=1S/C17H14F3N3O2/c1-2-3-4-25-16-10(7-21-17-11(16)8-22-23-17)15(24)14-12(19)5-9(18)6-13(14)20/h5-8H,2-4H2,1H3,(H,21,22,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 92 | n/a | n/a | n/a | n/a | 8.0 | 30 |
Bristol-Myers Squibb Company
| Assay Description The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ... |
Bioorg Med Chem Lett 13: 2405-8 (2003)
Article DOI: 10.1016/s0960-894x(03)00381-0 BindingDB Entry DOI: 10.7270/Q2ZS2TPW |
More data for this Ligand-Target Pair | |
CDK2/CycE
(Homo sapiens (Human)) | BDBM5775
(4-butoxy-5-[(2,4,6-trifluorophenyl)carbonyl]-1H-py...)Show SMILES CCCCOc1c(cnc2[nH]ncc12)C(=O)c1c(F)cc(F)cc1F Show InChI InChI=1S/C17H14F3N3O2/c1-2-3-4-25-16-10(7-21-17-11(16)8-22-23-17)15(24)14-12(19)5-9(18)6-13(14)20/h5-8H,2-4H2,1H3,(H,21,22,23) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
| Assay Description The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ... |
Bioorg Med Chem Lett 13: 2405-8 (2003)
Article DOI: 10.1016/s0960-894x(03)00381-0 BindingDB Entry DOI: 10.7270/Q2ZS2TPW |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 2
(Homo sapiens (Human)) | BDBM5775
(4-butoxy-5-[(2,4,6-trifluorophenyl)carbonyl]-1H-py...)Show SMILES CCCCOc1c(cnc2[nH]ncc12)C(=O)c1c(F)cc(F)cc1F Show InChI InChI=1S/C17H14F3N3O2/c1-2-3-4-25-16-10(7-21-17-11(16)8-22-23-17)15(24)14-12(19)5-9(18)6-13(14)20/h5-8H,2-4H2,1H3,(H,21,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University
Curated by ChEMBL
| Assay Description Inhibition of CDK2 |
AAPS J 8: 204-21 (2006)
Article DOI: 10.1208/aapsj080125 BindingDB Entry DOI: 10.7270/Q2TX3GBS |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (Human)) | BDBM5775
(4-butoxy-5-[(2,4,6-trifluorophenyl)carbonyl]-1H-py...)Show SMILES CCCCOc1c(cnc2[nH]ncc12)C(=O)c1c(F)cc(F)cc1F Show InChI InChI=1S/C17H14F3N3O2/c1-2-3-4-25-16-10(7-21-17-11(16)8-22-23-17)15(24)14-12(19)5-9(18)6-13(14)20/h5-8H,2-4H2,1H3,(H,21,22,23) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University
Curated by ChEMBL
| Assay Description Inhibition of CDK1 |
AAPS J 8: 204-21 (2006)
Article DOI: 10.1208/aapsj080125 BindingDB Entry DOI: 10.7270/Q2TX3GBS |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 4
(Homo sapiens (Human)) | BDBM5775
(4-butoxy-5-[(2,4,6-trifluorophenyl)carbonyl]-1H-py...)Show SMILES CCCCOc1c(cnc2[nH]ncc12)C(=O)c1c(F)cc(F)cc1F Show InChI InChI=1S/C17H14F3N3O2/c1-2-3-4-25-16-10(7-21-17-11(16)8-22-23-17)15(24)14-12(19)5-9(18)6-13(14)20/h5-8H,2-4H2,1H3,(H,21,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Georgetown University
Curated by ChEMBL
| Assay Description Inhibition of CDK4 |
AAPS J 8: 204-21 (2006)
Article DOI: 10.1208/aapsj080125 BindingDB Entry DOI: 10.7270/Q2TX3GBS |
More data for this Ligand-Target Pair | |
Cyclin-Dependent Kinase 4 (CDK4)
(Homo sapiens (Human)) | BDBM5775
(4-butoxy-5-[(2,4,6-trifluorophenyl)carbonyl]-1H-py...)Show SMILES CCCCOc1c(cnc2[nH]ncc12)C(=O)c1c(F)cc(F)cc1F Show InChI InChI=1S/C17H14F3N3O2/c1-2-3-4-25-16-10(7-21-17-11(16)8-22-23-17)15(24)14-12(19)5-9(18)6-13(14)20/h5-8H,2-4H2,1H3,(H,21,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 690 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company
| Assay Description The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ... |
Bioorg Med Chem Lett 13: 2405-8 (2003)
Article DOI: 10.1016/s0960-894x(03)00381-0 BindingDB Entry DOI: 10.7270/Q2ZS2TPW |
More data for this Ligand-Target Pair | |