BDBM5833 3-{4-[methyl({2-[(4-sulfamoylphenyl)amino]pyrimidin-4-yl})amino]phenyl}-1-[4-(trifluoromethoxy)phenyl]urea::urea deriv. 24
SMILES: CN(c1ccc(NC(=O)Nc2ccc(OC(F)(F)F)cc2)cc1)c1ccnc(Nc2ccc(cc2)S(N)(=O)=O)n1
InChI Key: InChIKey=BZDKOFCRFQFKOH-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM5833 (3-{4-[methyl({2-[(4-sulfamoylphenyl)amino]pyrimidi...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.5 | 22 |
GlaxoSmithKline | Assay Description The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl... | Bioorg Med Chem Lett 15: 3519-23 (2005) Article DOI: 10.1016/j.bmcl.2005.05.096 BindingDB Entry DOI: 10.7270/Q2KK990W | |||||||||||
More data for this Ligand-Target Pair |