BDBM60587 3-(3-fluoro-4-{1H-pyrrolo[2,3-b]pyridin-4-yloxy}phenyl)-1-[(4-fluorophenyl)methyl]urea (2)

SMILES: Fc1ccc(CNC(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)cc1

InChI Key: InChIKey=IDRYNPKIMNXUCO-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 60587   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine kinase receptor c-Met (c-Met) (Homo sapiens (Human))	BDBM60587 (3-(3-fluoro-4-{1H-pyrrolo[2,3-b]pyridin-4-yloxy}ph...) Show SMILES Fc1ccc(CNC(=O)Nc2ccc(Oc3ccnc4[nH]ccc34)c(F)c2)cc1 Show InChI InChI=1S/C21H16F2N4O2/c22-14-3-1-13(2-4-14)12-26-21(28)27-15-5-6-19(17(23)11-15)29-18-8-10-25-20-16(18)7-9-24-20/h1-11H,12H2,(H,24,25)(H2,26,27,28)	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	7.0	25
Tianjin University of Science and Technology					Assay Description The c-Met kinase activity of five target compounds and three positive compounds were evaluated using standard Z-LYTE Assays (fluorescence resonance e...				Bioorg Chem 65: 146-58 (2016) Article DOI: 10.1016/j.bioorg.2016.02.009 BindingDB Entry DOI: 10.7270/Q2VT1QVX
					More data for this Ligand-Target Pair