BDBM60588 3-(3-fluoro-4-{[2-(pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]oxy}phenyl)-1-[(4-fluorophenyl)methyl]urea (2a)

SMILES: Fc1ccc(CNC(=O)Nc2ccc(Oc3ccnc4[nH]c(cc34)-c3cccnc3)c(F)c2)cc1

InChI Key: InChIKey=KTGUUFMYIQNFHH-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 60588   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine kinase receptor c-Met (c-Met) (Homo sapiens (Human))	BDBM60588 (3-(3-fluoro-4-{[2-(pyridin-3-yl)-1H-pyrrolo[2,3-b]...) Show SMILES Fc1ccc(CNC(=O)Nc2ccc(Oc3ccnc4[nH]c(cc34)-c3cccnc3)c(F)c2)cc1 Show InChI InChI=1S/C26H19F2N5O2/c27-18-5-3-16(4-6-18)14-31-26(34)32-19-7-8-24(21(28)12-19)35-23-9-11-30-25-20(23)13-22(33-25)17-2-1-10-29-15-17/h1-13,15H,14H2,(H,30,33)(H2,31,32,34)	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	7.0	25
Tianjin University of Science and Technology					Assay Description The c-Met kinase activity of five target compounds and three positive compounds were evaluated using standard Z-LYTE Assays (fluorescence resonance e...				Bioorg Chem 65: 146-58 (2016) Article DOI: 10.1016/j.bioorg.2016.02.009 BindingDB Entry DOI: 10.7270/Q2VT1QVX
					More data for this Ligand-Target Pair