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BDBM60657 US9145402, 5

SMILES: CNc1nc(Nc2ccc(cc2OC)C#N)ncc1Cl

InChI Key: InChIKey=LBJUSKJCPFJNIK-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 60657   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM60657
PNG
(US9145402, 5)
Show SMILES CNc1nc(Nc2ccc(cc2OC)C#N)ncc1Cl
Show InChI InChI=1S/C13H12ClN5O/c1-16-12-9(14)7-17-13(19-12)18-10-4-3-8(6-15)5-11(10)20-2/h3-5,7H,1-2H3,(H2,16,17,18,19)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
8n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. In 3...


US Patent US9145402 (2015)


BindingDB Entry DOI: 10.7270/Q2J67FQ3
More data for this
Ligand-Target Pair