BDBM6125 3-quinolinecarbonitrile 13::4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-(2-methoxyethoxy)quinoline-3-carbonitrile
SMILES: COCCOc1cc2ncc(C#N)c(Nc3cc(OC)c(Cl)cc3Cl)c2cc1OC
InChI Key: InChIKey=RFMNZXCDCPAELC-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM6125 (3-quinolinecarbonitrile 13 | 4-[(2,4-dichloro-5-me...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research | Assay Description Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra... | Bioorg Med Chem Lett 13: 3797-800 (2003) Article DOI: 10.1016/j.bmcl.2003.07.001 BindingDB Entry DOI: 10.7270/Q27942VF | |||||||||||
More data for this Ligand-Target Pair |