BDBM61401 3,3-diphenyl-N-(1-phenylethyl)-1-propanamine;hydrochloride::3,3-diphenyl-N-(1-phenylethyl)propan-1-amine;hydrochloride::3,3-diphenylpropyl(1-phenylethyl)amine;hydrochloride::CHEMBL254832::FENDILINE HYDROCHLORIDE::MLS000069570::SMR000058827::cid_5702162
SMILES: CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1
InChI Key: InChIKey=NMKSAYKQLCHXDK-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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5-hydroxytryptamine receptor 2B (Homo sapiens (Human)) | BDBM61401 (3,3-diphenyl-N-(1-phenylethyl)-1-propanamine;hydro...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Similars | Article PubMed | 3.22E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of North Carolina at Chapel Hill Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting | J Med Chem 53: 7573-86 (2010) Article DOI: 10.1021/jm100600y BindingDB Entry DOI: 10.7270/Q2S182RT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Voltage-dependent L-type calcium channel subunit alpha-1C (Cavia porcellus) | BDBM61401 (3,3-diphenyl-N-(1-phenylethyl)-1-propanamine;hydro...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Jagiellonian University Curated by ChEMBL | Assay Description Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes | J Appl Toxicol 32: 858-66 (2012) Article DOI: 10.1002/jat.2784 BindingDB Entry DOI: 10.7270/Q2D79D5C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calmodulin (Bos taurus) | BDBM61401 (3,3-diphenyl-N-(1-phenylethyl)-1-propanamine;hydro...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari 'Aldo Moro' Curated by ChEMBL | Assay Description Binding affinity to bovine brain CaM by FTPFACE analysis | Eur J Med Chem 116: 36-45 (2016) BindingDB Entry DOI: 10.7270/Q2Q2424Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transcriptional activator protein luxR (Vibrio fischeri) | BDBM61401 (3,3-diphenyl-N-(1-phenylethyl)-1-propanamine;hydro...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
INSA Curated by ChEMBL | Assay Description Inhibition of LuxR-dependent quorum sensing in Vibrio fischeri assessed as reduction of 3-oxo-C6-HSL-induced bioluminescence intensity | Bioorg Med Chem Lett 20: 4355-8 (2010) Article DOI: 10.1016/j.bmcl.2010.06.081 BindingDB Entry DOI: 10.7270/Q27945N0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calmodulin (Bos taurus) | BDBM61401 (3,3-diphenyl-N-(1-phenylethyl)-1-propanamine;hydro...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari 'Aldo Moro' Curated by ChEMBL | Assay Description Binding affinity to dansylated bovine brain CaM assessed as half maximal increase in fluorescence by fluorescence analysis | Eur J Med Chem 116: 36-45 (2016) BindingDB Entry DOI: 10.7270/Q2Q2424Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calcium-sensing receptor (CaSR) (Homo sapiens (Human)) | BDBM61401 (3,3-diphenyl-N-(1-phenylethyl)-1-propanamine;hydro...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
Galapagos SASU Curated by ChEMBL | Assay Description Positive allosteric modulation of human CaSR transfected in CHO cells after 5 hrs by luciferase reporter gene assay | Bioorg Med Chem Lett 23: 2451-4 (2013) Article DOI: 10.1016/j.bmcl.2013.01.078 BindingDB Entry DOI: 10.7270/Q2930VJZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G-protein coupled receptor 55 (Homo sapiens (Human)) | BDBM61401 (3,3-diphenyl-N-(1-phenylethyl)-1-propanamine;hydro...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Similars | PCBioAssay | n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Burnham Center for Chemical Genomics Curated by PubChem BioAssay | Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C... | PubChem Bioassay (2010) BindingDB Entry DOI: 10.7270/Q2348HSG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Calmodulin (Bos taurus) | BDBM61401 (3,3-diphenyl-N-(1-phenylethyl)-1-propanamine;hydro...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari 'Aldo Moro' Curated by ChEMBL | Assay Description Binding affinity to dansylated bovine testes CaM by fluorescence analysis in presence of calcium2+ | Eur J Med Chem 116: 36-45 (2016) BindingDB Entry DOI: 10.7270/Q2Q2424Z | |||||||||||
More data for this Ligand-Target Pair |