null

SMILES: CCN(CC)CCCCCNc1cc2nc(NC(=O)NC(C)(C)C)c(cc2cn1)-c1cc(OC)cc(OC)c1

InChI Key: InChIKey=SDTAEHMYBHWTDK-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 6157   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Mus musculus (mouse))	BDBM6157 (1,6-naphthyridine 26 | 3-tert-butyl-1-(7-{[5-(diet...) Show SMILES CCN(CC)CCCCCNc1cc2nc(NC(=O)NC(C)(C)C)c(cc2cn1)-c1cc(OC)cc(OC)c1 Show InChI InChI=1S/C30H44N6O3/c1-8-36(9-2)14-12-10-11-13-31-27-19-26-22(20-32-27)17-25(21-15-23(38-6)18-24(16-21)39-7)28(33-26)34-29(37)35-30(3,4)5/h15-20H,8-14H2,1-7H3,(H,31,32)(H2,33,34,35,37)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland					Assay Description Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...				J Med Chem 48: 4628-53 (2005) Article DOI: 10.1021/jm0500931 BindingDB Entry DOI: 10.7270/Q2DV1H3W
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM6157 (1,6-naphthyridine 26 | 3-tert-butyl-1-(7-{[5-(diet...) Show SMILES CCN(CC)CCCCCNc1cc2nc(NC(=O)NC(C)(C)C)c(cc2cn1)-c1cc(OC)cc(OC)c1 Show InChI InChI=1S/C30H44N6O3/c1-8-36(9-2)14-12-10-11-13-31-27-19-26-22(20-32-27)17-25(21-15-23(38-6)18-24(16-21)39-7)28(33-26)34-29(37)35-30(3,4)5/h15-20H,8-14H2,1-7H3,(H,31,32)(H2,33,34,35,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland					Assay Description Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...				J Med Chem 48: 4628-53 (2005) Article DOI: 10.1021/jm0500931 BindingDB Entry DOI: 10.7270/Q2DV1H3W
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM6157 (1,6-naphthyridine 26 | 3-tert-butyl-1-(7-{[5-(diet...) Show SMILES CCN(CC)CCCCCNc1cc2nc(NC(=O)NC(C)(C)C)c(cc2cn1)-c1cc(OC)cc(OC)c1 Show InChI InChI=1S/C30H44N6O3/c1-8-36(9-2)14-12-10-11-13-31-27-19-26-22(20-32-27)17-25(21-15-23(38-6)18-24(16-21)39-7)28(33-26)34-29(37)35-30(3,4)5/h15-20H,8-14H2,1-7H3,(H,31,32)(H2,33,34,35,37)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland					Assay Description Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...				J Med Chem 48: 4628-53 (2005) Article DOI: 10.1021/jm0500931 BindingDB Entry DOI: 10.7270/Q2DV1H3W
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM6157 (1,6-naphthyridine 26 | 3-tert-butyl-1-(7-{[5-(diet...) Show SMILES CCN(CC)CCCCCNc1cc2nc(NC(=O)NC(C)(C)C)c(cc2cn1)-c1cc(OC)cc(OC)c1 Show InChI InChI=1S/C30H44N6O3/c1-8-36(9-2)14-12-10-11-13-31-27-19-26-22(20-32-27)17-25(21-15-23(38-6)18-24(16-21)39-7)28(33-26)34-29(37)35-30(3,4)5/h15-20H,8-14H2,1-7H3,(H,31,32)(H2,33,34,35,37)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland					Assay Description Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...				J Med Chem 48: 4628-53 (2005) Article DOI: 10.1021/jm0500931 BindingDB Entry DOI: 10.7270/Q2DV1H3W
					More data for this Ligand-Target Pair